Cancer progression and metastasis largely depend upon the interactions between cancer cells and their microenvironment. In this review, the involvement of TERT in the tumour microenvironment and the underlying implications in cancer therapeutics have been summarized....
Telomerase is a relatively specific cancer target as normal body cells express little or no telomerase for most of their lifespan and generally have longer telomeres than those in tumour cells. Two major approaches to killing telomerase-positive tumour cells are in clinical trials. A direct telomera...
Telomerase has been shown to cooperate with oncogenes in transforming cultured primary human cells into neoplastic cells, suggesting that telomerase activation contributes to malignant transformation. Moreover, telomerase inhibition in human tumour cell lines using dominant-negative versions of TERT leads to...
Somatic cells express genes that suppress telomerase activity and these genes may be inactivated in tumour cells. We postulated that cancer cells acquire immortality by activation of telomerase by the loss of such a gene. We have reported recently that a telomerase repressor gene may be located on...
Notably, telomerase activity of these tissues and cell lines was comparable; however, we detected binding of TERT to rDNA exclusively in tumour cells and transformed cells (Fig. 2a). In addition, telomerase exhibited strong binding to rDNA in human hepatocellular carcinoma cells (Supplementary Fig....
It is emphasized that cancer stem cells (CSCs) forming the subpopulation of tumour cells are responsible for tumour growth, metastasis, and cancer drug resistance. Inadequate response to conventional therapy in breast cancer leads researchers to find new treatment methods and literature surveys that ...
Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells APOPTOSISTELOMERES AND TELOMERASEGLIOBLASTOMA AND MEDULLOBLASTOMACurcumin, a polyphenolic compound isolated from Curcuma longa (Turmeric) is widely used in ... Aik,Kia,Khaw,... - 《Journal of Cellular Biochemi...
Telomeres in cancer: tumour suppression and genome instability. Nat. Rev. Mol. Cell. Biol. 18, 175–186 (2017). Article CAS PubMed PubMed Central Google Scholar Shay, J. W. Role of telomeres and telomerase in aging and cancer. Cancer Discov. 6, 584–593 (2016). Article CAS PubMed...
Epidermal growth factor activates telomerase activity by direct binding of Ets-2 to hTERT promoter in lung cancer cells. Tumour Biol. 2015. https://doi.org/10.1007/s13277-015-3204-x23. Article PubMed Google Scholar Chan AK, Yao Y, Zhang Z, Chung NY, Liu JS, Li KK, Shi Z, Chan DT...
Tumour cells marked by indefinite proliferation have stable telomere length maintained by telomerase. The differential expression of the telomerase enzyme in normal and cancer cells have led to the evolution of tumour specific anti-telomerase approaches which inhibit the telomerase enzyme activity so as ...