2g). However, in contrast to the 3′ bulge, this 5′ bulge resides on the other strand of the stem, so that the 5′ H/ACA hairpin makes a turn to the opposite direction towards the catalytic core of the holoenzyme (Fig. 2a, g; Supplementary information, Fig. S6c). Collectively, ...
Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 266(5193):2011–2015 Article CAS Google Scholar Wright WE, Pereira-Smith OM, Shay...
This relationship between activation of telomerase activity and short telomeres in human malignancies makes the inhibition of telomerase a valuable target for cancer therapeutics. Importantly, the mode of action of telomerase inhibitors predicts minimal side effects on normal stem cells that can express ...
The invention relates to a method for immortalizing a human periodontal ligament stem cell line by using an hTERT (human telomerase reverse transcriptase) lentivirus recombinant. The method comprises the following steps: 1, culturing primary human periodontal ligament stem cells (hPDLSC); 2, ...
Studies have shown that sleep, meditation, and exercise all improve health because they activate telomerase, an enzyme that heals your stem cells and immune system. This has been ... 分享回复赞 nmn吧 一起压倒一切 NMN破解上帝密码?三个男人和骗子的战斗20世纪之初,NMN之父Hans.Von.Elux-cherpin(...
In telomerase-positive cells (e.g. human stem cells, ciliates and yeast) telomeres can be extended and hence maintained, while in telomerase-negative cells (e.g. human somatic cells) telomere extension doesn’t happen and eventually cells enter replicative senescence. Ever since the initial ...
Conclusions Telomerase is a diagnostic and therapeutic biomarker because it is absent from most somatic cells and is present in most cancer cells. The relationship between telomerase and cancer is complex, which makes it a distinctive target for cancer therapy. Telomerase synergistically with natural ...
Telomerase activity is prominent in highly proliferative cells such as stem cells, germ line cells, as well as 90% of human cancers (Kim et al., 1994), which makes it as a main target for cancer treatment. There are two general strategies of targeting telomerase in cancer treatmen...
It adds repeats sequence to the end of the chromosome by using TERC as a template, so as to keep the telomere length stable and alleviate cell senescence6. Previous evidence has shown that telomerase activity in cancer cells and stem cells is higher than that in somatic cells7. Human ...
Lue NF (2004) Adding to the ends: what makes telomerase processive and how important is it? Bioessays 26:955–962 Article CAS PubMed Google Scholar Miura T, Katakura Y, Yamamoto K, Uehara N, Tsuchiya T, Kim EH, Shirahata S (2001) Neural stem cells lose telomerase activity upon differ...