12.Mollasalehi, N., et al., An allosteric modulator of RNA binding targeting the N-terminal domain of TDP-43 yields neuroprotective properties. ACS chemical biology, 2020. 15(11): p. 2854-2859. 13.Ni, J., et...
Recently published articles on these subjects have been reviewed in the writing up of this manuscript.Targeting aberrant TDP-43 aggregation in neurodegenerative diseases should be considered both a challenge and an opportunity. The challenge is represented by the central role played by TDP-43 in the...
[8] Buratti E. Targeting TDP-43 proteinopathy with drugs and drug-like small molecules. Br J Pharmacol. 2021 Mar;178(6):1298-1315. [9] ALS News Today. (n.d.). ALS Gene Therapy SOL-257 Targeting TDP-43 Shows Promise in Mouse Model. Retrieved from https://alsnewstoday.com/news/als...
Targeting TDP-43 proteinopathy with drugs and drug-like small molecules. Br J Pharmacol. 2021 Mar;178(6):1298-1315. [9] ALS News Today. (n.d.). ALS Gene Therapy SOL-257 Targeting TDP-43 Shows Promise in Mouse Model. Retrieved from alsnewstoday.com/news/a [10] ALS News Today. (...
因此,这些特征对于开发灵敏且具有特异性的诊断和治疗而言至关重要。这样的tdp-43亚种的高亲和力和选择性靶向对于tdp-43蛋白质病而言特别重要,因为tdp-43聚集可导致对tdp-43功能的显性负性作用,其如果与功能性tdp-43的无意靶向(inadvertenttargeting)相组合的话可加剧疾病。tdp-43蛋白质病的预防和治疗...
focusing on its physiological and pathological functions, as well as its involvement in the pathogenesis of neurodegenerative disorders. We will also discuss the potential therapeutic strategies targeting TDP-43 and the challenges associated with developing effective treatments for TDP-43-related diseases. ...
To optimize the ICW technique for screening TDP43 targeting drugs, N9 cells were seeded in a 96-well plate and processed for ICW by using various dilution of TDP43 antibody. TDP43 antibody, used at a dilution of 1:1000, provided sufficient signal for detection (Fig. 1A). For drug screeni...
In the process of developing new TDP-43-targeting bioassays, we discovered that TDP-43 levels are low in the non-cellular phase of blood plasma but that TDP-43 is highly concentrated in platelets. Here we describe our analyses and consider the potential biological significance of this localizatio...
focusing on its physiological and pathological functions, as well as its involvement in the pathogenesis of neurodegenerative disorders. We will also discuss the potential therapeutic strategies targeting TDP-43 and the challenges associated with developing effective treatments for TDP-43-related diseases. ...
The TDP-43 proteinopathies, which include amyotrophic lateral sclerosis and frontotemporal dementia, are a devastating group of neurodegenerative disorders that are characterized by the mislocalization and aggregation of TDP-43. Here we demonstrate that RNA-targeting CRISPR effector proteins, a program...