近期,EMBO J.上发表了题为“Loss of TDP-43 oligomerization or RNA binding elicits distinct aggregation patterns”的文章,揭示了寡聚和RNA结合控制着TDP-43的稳定性、剪接功能、LLPS和亚细胞定位。作者着重提出,TDP-43的寡聚是由RNA...
2. B. S. Johnson et al., TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity. J. Biol. Chem. 284, 20329–20339 (2009). doi: 10.1074/jbc.M109.010264;pmid: 19465477 3. T. Arai et al., TDP-43 is a com...
2. B. S. Johnson et al., TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity.J. Biol. Chem.284, 20329–20339 (2009). doi: 10.1074/jbc.M109.010264;pmid: 19465477 3. T. Arai et al., TDP-43 is a compone...
1. Ayala, Y. M. et al. Structural determinants of the cellular localization and shuttling of TDP- 43.J. Cell Sci. 121, 3778–3785 (2008). 2. Afroz, T. et al. Functional and dynamic polymerization of the ALS-linked protein TDP-4...
The agent for prevention or treatment of neurodegenerative diseases induced by abnormal accumulation of TDP-43 in cells comprises such nucleic acid as an active ingredient.YOKOTA TakanoriSAKAUE Fumika
Protein aggregation plays key roles in age-related degenerative diseases, but how different proteins coalesce to form inclusions that vary in composition, morphology, molecular dynamics and confer physiological consequences is poorly understood. Here we employ a general reporter based on mutant Hsp104 to...
TDP-43 protein plays an important role in regulating transcriptional repression, RNA metabolism and splicing. Typically it shuttles between the nucleus and the cytoplasm to perform its functions, while abnormal cytoplasmic aggregation of TDP-43 has been
The immunoreactivity was distributed in selected anatomical areas, suggesting that TDP-43 aggregation might be involved in the AD pathogenesis.doi:10.1016/j.jalz.2008.05.2228Yamazaki, TsuneoNakasone, AiTakatama, MasamitsuLemere, CynthiaOkamoto, Koichi...
We review the relationship of stress granules and TDP-43 pathological aggregation. We propose two possible models for TDP-43 aggregate formation. In one model, TDP-43 aggregation is "independent" of stress granule formation. In another model, stress granules are "precursors" to TDP-43 aggregation...
Again we found reduced aggregation, in this case of wild type TDP-43, but no difference in cell death. Conclusions: Our results suggest that TDP-43 aggregation is associated with the cell death process rather than being a direct cause. 展开 ...