TARDBP (TDP-43) sequence analysis in patients with familial and sporadic ALS: identification of two novel mutations. Eur J Neurol. 2009; 16:727-32. [PubMed: 19236453]Del Bo, R., Ghezzi, S., Corti, S., Pandolfo, M., Ranieri, M., Santoro, D., Ghione, I., Prelle, A., Orsetti...
Here, we show distinct roles of RRM1 and RRM2 in the sequence-specific substrate recognition of TDP-43. RRM1 was found to bind a wide spectrum of ssDNA sequences, while no binding was observed between RRM2 and ssDNA. When two RRMs are fused in tandem as in native TDP-43, the fused ...
279 and 360 likely formed the amyloid core of TDP-43 (Fig.4e). Surprisingly, the sequence of the amyloid CP is almost identical to the sequence (281–360) determined from brain-derived pathological TDP-43 protein from individuals with a clinical history of ALS with FTLD23. Consistent with t...
Multiple studies have provided evidence that TDP-43 acts as a protective factor in individuals during viral infections. Ou et al. first cloned and characterized TDP-43 in 1995, demonstrating its binding to the TAR sequence motifs of HIV-1 and inhibition ofHIV-1gene expression [2]. Although su...
The authors' analysis shows that in the absence of TDP-43, a large set of TEs get turned on. While other labs have shown that unsettling things happen to TEs without TDP-43, the elements themselves are difficult to analyze because their sequences are so similar to each other. By looking...
(ASOs) suppressed cryptic splicing, which restored axonal regeneration and stathmin-2–dependent lysosome trafficking in TDP-43–deficient human motor neurons. In mice that were gene-edited to contain human STMN2 cryptic splice-polyadenylation sequences, ASO injection into cerebral spinal fluid ...
43kDa Tar DNA结合蛋白(TDP43)重组蛋白SEQUENCES The sequence of the target protein is listed below.MGHHHHHHSGSEF- SDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA QSLCGEDLII KGISVHISNA...
TDP-43 was initially identified in 1995 as a protein that binds to pyrimidine-rich motifs of TAR DNA sequence in the HIV type 1 gene and modulates the HIV-1 gene expression (Ou et al., 1995). However, for the first time in 2006, it was reported that TDP-43 is the main protein com...
TDP-43 is a highly conserved nuclear factor of yet unknown function that binds to ug-repeated sequences and is responsible for cystic fibrosis transmembran... E Buratti,A Brindisi,M Giombi,... - 《Journal of Biological Chemistry》 被引量: 1660发表: 2005年 Long pre-mRNA depletion and RNA...
(detected by probes 6–9) relative to 28S rRNA staining compared with a mock knockdown with a sequence-scrambled RNA (scRNA; Supplementary Fig.3d). All these processing intermediates accumulated in the TDP-43-overexpressing cells (Fig.5a–c). Thus, the phenotype observed with mitochondrial ...