The invention also provides for an army comprising the nucleic acids and peptides of the invention.ケアンズ,ナイジェル,ジェイ.バロー,ロバート,エイチ.ペストロンク,アランギッチョー,マイケル,エー.ゴート,アリソン,エム.
However, since wild-type TDP-43 does not form cytoplasmic condensates in Neuro2a cells23, we used an aggregate-prone mutant of TDP-43 (C173/175S and mutation in nuclear localization signal sequence; TDP43CS) (Supplementary Fig. 6a) and expressed in human embryonic kidney 293 cells. Cells ...
(detected by probes 6–9) relative to 28S rRNA staining compared with a mock knockdown with a sequence-scrambled RNA (scRNA; Supplementary Fig.3d). All these processing intermediates accumulated in the TDP-43-overexpressing cells (Fig.5a–c). Thus, the phenotype observed with mitochondrial ...
Sequence- Gene ID23435 SwissProtQ13148 SynonymsTDP43 CategoryTranscription Factors BackgroundRNA结合蛋白,参与RNA生物形成和加工的各个步骤。通过两个RNA识别基序RRM1和RRM2,GU优先结合在RNA分子上,这些RNA分子主要定位在长内含子和mRNAs的3'UTR中。反过来,调节许多非编码和蛋白质编码的RNA的剪接,包括涉及神经元存活的...
产品信息 应用 建议稀释比 已发表文章 免疫印迹 (WB) 1:500-1:3,000 - 免疫组化(石蜡) (IHC (P)) 1:100-1:1,000 - 产品规格 种属反应 Human,Mouse,Rat 宿主/亚型 Mouse / IgG2b 分类 Monoclonal 类型 Antibody 克隆号 GT225 抗原 Recombinant protein encompassing a sequence within the center region...
TDP-43 directly binds the mature sequences of a subset of the TDP-43 regulated miRNAs, including miR-423-3p and miR-500a-3p. We identified several putative TDP-43-regu- lated miRNAs that are closely associated with cancers, especially lung cancer. A functional annotation pipeline ...
The unraveling of TDP-43’s involvement in neurodegenerative conditions has been a gradual process spanning more than 20 years (Fig.2). Initially identified in 1995 as a protein interacting with the TAR DNA sequence in HIV-1, thus modulating viral gene expression [6], TDP-43’s relevance to...
Ready-to-use high expression level TDP-43/TARDBP cDNA clones are full sequence confirmed with various fusion tags, 2 in lentiviral vector, 26 in expression vector, 2 in cloning vector also available.
The structure of TDP-43 is composed of an N-terminal domain, a nuclear localization sequence (NLS), two RNA binding domains (RBD1 and RBD2), a nuclear export signal (NES), and a C-terminal glycine rich domain (GRD) (Fig1) [34]. The protein also has an amyloidogenic core region (...
Here, we show distinct roles of RRM1 and RRM2 in the sequence-specific substrate recognition of TDP-43. RRM1 was found to bind a wide spectrum of ssDNA sequences, while no binding was observed between RRM2 and ssDNA. When two RRMs are fused in tandem as in native TDP-43, the fused ...