TARDBP (TDP-43) sequence analysis in patients with familial and sporadic ALS: identification of two novel mutations. Eur J Neurol. 2009; 16:727-32. [PubMed: 19236453]Del Bo, R., Ghezzi, S., Corti, S., Pandolfo, M., Ranieri, M., Santoro, D., Ghione, I., Prelle, A., Orsetti...
Here, we show distinct roles of RRM1 and RRM2 in the sequence-specific substrate recognition of TDP-43. RRM1 was found to bind a wide spectrum of ssDNA sequences, while no binding was observed between RRM2 and ssDNA. When two RRMs are fused in tandem as in native TDP-43, the fused ...
43kDa Tar DNA结合蛋白(TDP43)重组蛋白SEQUENCES The sequence of the target protein is listed below.MGHHHHHHSGSEF- SDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA QSLCGEDLII KGISVHISNA...
(detected by probes 6–9) relative to 28S rRNA staining compared with a mock knockdown with a sequence-scrambled RNA (scRNA; Supplementary Fig.3d). All these processing intermediates accumulated in the TDP-43-overexpressing cells (Fig.5a–c). Thus, the phenotype observed with mitochondrial ...
[ SEQUENCE ] [ IDENTIFICATION ] Figure . Gene Sequencing (extract) [ IMPORTANT NOTE ] The kit is designed for research use only, we will not be responsible for any issue if the kit was used in clinical diagnostic or any other procedures. ...
43kDa Tar DNA结合蛋白(TDP43)重组蛋白The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSGSEF- SDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADD...
Introduction Encoded by theTARDBPgene, TDP-43 is highly conserved across various species [1]. The protein was initially recognized as a transcription repressor (with a size of 43 kD, hence its name), exhibiting affinity for the TAR DNA sequence of human immunodeficiency virus type 1 (HIV-1)...
The authors' analysis shows that in the absence of TDP-43, a large set of TEs get turned on. While other labs have shown that unsettling things happen to TEs without TDP-43, the elements themselves are difficult to analyze because their sequences are so similar to each other. By looking...
(ASOs) suppressed cryptic splicing, which restored axonal regeneration and stathmin-2–dependent lysosome trafficking in TDP-43–deficient human motor neurons. In mice that were gene-edited to contain human STMN2 cryptic splice-polyadenylation sequences, ASO injection into cerebral spinal fluid ...
TDP-43 is a highly conserved nuclear factor of yet unknown function that binds to ug-repeated sequences and is responsible for cystic fibrosis transmembran... E Buratti,A Brindisi,M Giombi,... - 《Journal of Biological Chemistry》 被引量: 1660发表: 2005年 Long pre-mRNA depletion and RNA...