The underlying mechanism is TDP43-CTFs35-mediated inhibition of Hippo signaling pathway activity through the dephosphorylation of MST1/2, which leads to the inhibition of YAP phosphorylation and the subsequent impairment of brain EC migration and tight junction protein expression. This study provides ...
In conclusion, the new cellular model mimics classical toxic TDP-43 cellular model and interestingly the toxicity of CTF25 is dependent on the proteasome.doi:10.1016/j.neuroscience.2014.09.043Liu, Y.Duan, W.Guo, Y.Li, Z.Han, H.Zhang, S....
A new cellular model of pathological TDP-43: The neurotoxicity of stably expressed CTF25 of TDP-43 depends on the proteasome. Neuroscience. 2014;281C:88-98.Liu, Y., Duan, W., Guo, Y., et al. A new cellular model of pathological TDP-43: The neurotoxicity of stably expressed CTF25 ...
Effect of selected kinase inhibitors on aggregation of CTF-TDP-43-GFP (219–414).Diane, MoujalledJanine L., JamesSarah, J. ParkerGrace, E. LidgerwoodClare, DuncanJodi, MeyerowitzTakashi, NonakaMasato, HasegawaKatja, M. KanninenAlexandra, Grubman...
The 25 kDa CTF binds to TDP-43 lacking the RNP2 motif.Shinnosuke TakagiYohei IguchiMasahisa KatsunoShinsuke IshigakiKensuke IkenakaYusuke FujiokaDaiyu HondaJunichi NiwaFumiaki TanakaHirohisa Watanabe