Finally, previous studies have shown that RBM45 accumulates in cytoplasmic inclusions in the brains of patients with amyotrophic lateral sclerosis (ALS) or frontotemporal lobar degeneration (FTLD) and that it interacts with other RBPs that form aggregates in diseased brains, including FUS and TDP-43...
The methyltransferase complex (MTC) deposits N6-adenosine (m6A) onto RNA, whereas the microprocessor produces microRNA. Whether and how these two distinct complexes cross-regulate each other has been poorly studied. Here we report that the MTC subunit B
SG are transient structures that disassemble when the stress is over, but they can become pathological when stress is prolonged. Defects in both SG assembly and disassembly have been linked to neurodegenerative disorders3,5,6. Several mutant proteins associated with ALS, such as TDP-43 and FUS,...