Super-resolution microscopy of hCD34+ ATXN2 KO cells phenocopied the presence of disease-associated ALS (amyotrophic lateral sclerosis) stress granules with TDP-43, G3BP1/2, PABPC1, and Tia-1 enriched with m6A labeled RNAs. Using the K562 ALKBH5 KO erythropoiesis model and ATXN2 lentiviral ...
TDP43 aggregation at ER-exit sites impairs ER-to-Golgi transport Article Open access 19 October 2024 FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy Article Open access 01 April 2019 TDP-43 aggregation inside micronuc...
The methyltransferase complex (MTC) deposits N6-adenosine (m6A) onto RNA, whereas the microprocessor produces microRNA. Whether and how these two distinct complexes cross-regulate each other has been poorly studied. Here we report that the MTC subunit B
Finally, previous studies have shown that RBM45 accumulates in cytoplasmic inclusions in the brains of patients with amyotrophic lateral sclerosis (ALS) or frontotemporal lobar degeneration (FTLD) and that it interacts with other RBPs that form aggregates in diseased brains, including FUS and TDP-43...