TAR DNA结合蛋白43(TAR DNA-binding protein 43,TDP-43)是一种关键的DNA/RNA结合蛋白,主要定位于细胞核,同时也能在细胞核和细胞质之间移动,与多种RNA结合。在肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)等神经退行性疾病中,典型的病理特征...
1. Ayala, Y. M. et al. Structural determinants of the cellular localization and shuttling of TDP- 43.J. Cell Sci. 121, 3778–3785 (2008). 2. Afroz, T. et al. Functional and dynamic polymerization of the ALS-linked protein TDP-4...
[8] Buratti E. Targeting TDP-43 proteinopathy with drugs and drug-like small molecules. Br J Pharmacol. 2021 Mar;178(6):1298-1315. [9] ALS News Today. (n.d.). ALS Gene Therapy SOL-257 Targeting TDP-43 Shows Promise in Mouse Model. Retrieved from https://alsnewstoday.com/news/als...
Human TDP-43 Protein, His Tag 分子别名(Synonym) TAR DNA-binding protein 43 表达区间及表达系统(Source) Human TDP-43, His Tag (TD3-H5145) is expressed from E. coli cells. It contains AA Met 1 - Met 414 (Accession # Q13148-1). ...
Protein TDP-43 keeps genetic zombies at bay Reference: Yingzi Hou et al, TDP-43 chronic deficiency leads to dysregulation of transposable elements and gene expression by affecting R-loop and 5hmC crosstalk, Cell Reports (2024). DOI: 10.1016/j.celrep.2023.113662...
binding protein 43(tdp ‑ 43)是一种多功能的核蛋白,在转录、可变剪接、rna稳定性和基因调控中发挥着重要的作用。tdp ‑ 43病理是大多数肌萎缩侧索硬化症(als)和约50%的额颞叶变性(ftld)患者的疾病标志。编码tdp ‑ 43基因的突变与家族性和散发性als以及罕见的ftld病例相关,并产生毒性。tdp ...
[8] Buratti E. Targeting TDP-43 proteinopathy with drugs and drug-like small molecules. Br J Pharmacol. 2021 Mar;178(6):1298-1315. [9] ALS News Today. (n.d.). ALS Gene Therapy SOL-257 Targeting TDP-43 Shows Promise in Mouse Model. Retrieved fromhttps://alsnewstoday.com/news/als...
Cat No.10782-2-AP 浓度:800 ug/ml 库存:现货 点击咨询售前客服 点击咨询售后客服 mouseIF Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies See more citations 相关产品 14813-1-AP
Cleveland研究组、哈佛大学Clotilde Lagier-Tourenne研究组与加州大学圣地亚哥分校Ze’ev Melamed(共同第一作者)在Science发文题为Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies,发现TDP-43的错误定位会导致轴突再生蛋白stathmin-2前体mRNAs STMN2的隐蔽剪接以及多聚腺苷...