[8] Buratti E. Targeting TDP-43 proteinopathy with drugs and drug-like small molecules. Br J Pharmacol. 2021 Mar;178(6):1298-1315. [9] ALS News Today. (n.d.). ALS Gene Therapy SOL-257 Targeting TDP-43 Shows Promise in Mouse Model. Retrieved fromhttps://alsnewstoday.com/news/als-...
[8] Buratti E. Targeting TDP-43 proteinopathy with drugs and drug-like small molecules. Br J Pharmacol. 2021 Mar;178(6):1298-1315. [9] ALS News Today. (n.d.). ALS Gene Therapy SOL-257 Targeting TDP-43 Shows Promise in Mouse Model. Retrieved from https://alsnewstoday.com/news/als...
[8] Buratti E. Targeting TDP-43 proteinopathy with drugs and drug-like small molecules. Br J Pharmacol. 2021 Mar;178(6):1298-1315. [9] ALS News Today. (n.d.). ALS Gene Therapy SOL-257 Targeting TDP-43 Shows Promise in Mouse Model. Retrieved from https://alsnewstoday.com/news/als...
Aberrant aggregation of RNA binding protein TDP-43 in neurons is a hallmark of frontotemporal lobar degeneration caused by progranulin haploinsufficiency. However, the mechanism leading to TDP-43 proteinopathy remains unclear. Here we use single-nucleus RNA-sequencing (snRNA-seq) to show that ...
This issue introduces the TDP-43 proteinopathy research model - B6-hTARDBP mice (Product Number: C001418). In amyotrophic lateral sclerosis (ALS), pathological abnormalities of TDP-43 protein are almost universally present, regardless of whether theTARDBPgene is mutated. This indicates that TDP-43...
文章在《中国神经再生研究(英文版)》杂志2022年7 月7 期发表。 Keszycki R, Jamshidi P, Kawles A, Minogue G, Flanagan ME, Zaccard CR, Mesulam MM, Gefen T, Geula C (2022) Propagation of TDP-43 proteinopathy in neurodegenerative disorders. Neural Regen Res 17(7):1498-1500....
8 ✉Aberrant aggregation of the RNA-binding protein TDP-43 in neurons is a hallmark of frontotemporal lobar degeneration caused by haploinsuf f i ciency in the gene encoding progranulin 1,2 . However, the mechanism leading to TDP-43 proteinopathy remains unclear. Here we use single-...
43 pathology when programmed to target ataxin-2, a modifier of TDP-43-associated toxicity. In addition to inhibiting the aggregation and transit of TDP-43 to stress granules, we find that the in vivo delivery of an ataxin-2-targeting Cas13 system to a mouse model of TDP-43 proteinopa...
相关研究结果近期发表在Science Translational Medicine期刊上,论文标题为“C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy”。 特别地,毒性的poly(GR)蛋白以RNA不依赖的方式介导全长TDP-43的封存,从而诱导细胞质TDP-43包涵体形成。 此外,在GFP-(GR)200小鼠中,poly(GR)引起核质转运因子(nucleocytoplasmic...
TDP-43 Pathology in Alzheimer's Disease. PMID: 34930382 The Role of TDP-43 in Neurodegenerative Disease. PMID: 35499795 TDP-43 Proteinopathy Specific Biomarker Development. PMID: 36831264 Emerging Therapies and Novel Targets for TDP-43 Proteinopathy in ALS/FTD. PMID: 35790708 ...