Swiss Prot: Q13148 Gene ID: 23435 交叉反应: Human Mouse (Chicken Gorilla) 分子量: 31kDa 区间范围: 1-276aa 背景说明: This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress.Catalase is a heme enzyme that is present in the peroxisome of nearly all...
By applying advanced microscopy, it was further shown that PROTAC2decreased the compactness and population of C-TDP-43 oligomers. In addition to cellular model, PROTAC2also improved the motility of transgenicC. elegansby reducing the C-TDP-43 aggregates in the nervous system.#Our study ...
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A sulfo-tag conjugated anti-mouse secondary antibody (#R32AC-1) was obtained from MSD. Novel mouse monoclonal antibodies against human TDP-43 were generated by AC Immune. The SIMOA assay reported here utilized ACI-mAb-1 that binds to the RRM2 domain (Suppl. Fig. 7) and ACI-mAb-2 that ...
HyT method of targeting TDP-43 clearance is an interesting area and could be coupled by PROTAC (proteolysis targeting chimera) small molecules, in which is in its early stages for TDP-43 clearance purposes. PROTAC small molecules are composed of two domains in which one domain binds to a ...
IP of TDP‑43 from human ALS plasma Recombinant AC Immune anti-TDP-43 or control IgG2a monoclonal antibodies were coupled to M-270 Epoxy Dynabeads® (Invitrogen) with rotation for 24 h at 4 °C. After antibody coupling, the supernatant was removed Scientific Reports | (2024) 14:...