elegansby reducing the C-TDP-43 aggregates in the nervous system.#Our study demonstrated the dual-targeting capacity of the newly-designed PROTAC2against both C-TDP-43 aggregates and oligomers to reduce their neurotoxicity, which shed light on the potential drug development for ALS as well as...
产品编号:AC82114品牌:Acmec 产品介绍 技术文章 安全信息 相关论文 产品问答 中文名称: Recombin human TDP-43 protein 英文名称: Recombinant human TDP-43 protein 保存条件: -20°C 产品属性 Product Attributes 基本信息 基因名: TDP-43 别名: ALS10,TAR DNA binding protein,TAR DNA binding protein 43,TAR...
The TAR DNA Binding Protein 43 (TDP-43) has been implicated in the pathogenesis of human neurodegenerative diseases and exhibits hallmark neuropathology in amyotrophic lateral sclerosis (ALS). Here, we explore its tractability as a plasma biomarker of di
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;• 设有专业的实验中心和严格的质控、验证体系;• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检...
www.nature.com/scientificreports OPEN Location and function of TDP‑43 in platelets, alterations in neurodegenerative diseases and arising considerations for current plasma biobank protocols Ruth Luthi‑Carter 1*, Sara Cappelli 2, Morgan Le Roux‑Bourdieu 1, Noemie...
HyT method of targeting TDP-43 clearance is an interesting area and could be coupled by PROTAC (proteolysis targeting chimera) small molecules, in which is in its early stages for TDP-43 clearance purposes. PROTAC small molecules are composed of two domains in which one domain binds to a ...