Gendron TF, Josephs KA, Petrucelli L (2010) TDP-43: mechanisms of neu- rodegeneration. Neuropathol Appl Neurobiol. 36:97-112.Gendron, T.F., Josephs, K.A. & Petrucelli, L . (2010) Review: Transactive response DNA- binding protein 43 (TDP-43): mechanisms of neurodegeneration. ...
Functions of TDP-43 protein. TDP-43 functions as a nucleocytoplasmic shuttling protein via nuclear pores, which can regulate cellular functions at multiple levels. At the DNA level, TDP-43 is involved in gene transcription, DNA damage, and DNA replication. At the RNA level, TDP-43 is involved...
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(ALS), frontotemporal lobar degeneration (FTLD), and Alzheimer's disease (AD). This comprehensive review explores the multifaceted roles of TDP-43 in both physiological and pathological contexts. We delve into TDP-43's crucial functions in RNA metabolism, including splicing regulation, mRNA ...
Review 作者: Ventura, Salvador ; García-Pardo, Javier ; Bartolomé-Nafría, Andrea Heterogeneous nuclear ribonucleoproteins (hnRNPs) are multifunctional proteins with integral roles in RNA metabolism and the regulation of alternative splicing. These proteins typically contain prion-like domains of low ...
Research output:Contribution to journal›Article›peer-review 95Citations (Scopus) Abstract Until a couple of years ago, TAR-DNA-binding protein-43 (TDP-43) was a relatively unknown nuclear protein implicated in transcriptional repression and splicing. Since 2006, when the protein was reported ...
(TDP-43) has increased, leading to the new designation 'TDP-43 proteinopathy.' Biochemically, TDP-43 proteinopathies are characterized by decreased solubility, hyperphosphorylation, and cleavage of TDP-43 into 25- and 35-kDa fragments, and by altered cellular localization.This review summarizes ...
9.Sonoda K, Sasaki K, Tateishi T, et al: TAR DNA-binding protein 43 pathology in a case clinically diagnosed with facial-onset sensory and motor neuronopathy syndrome: an autopsied case report and a review of the literature. J Neurol Sci 2013;332:148-153. ...
Review: Transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration. Neuropathol Appl Neurobiol. 2010;36(2):97–112. https://doi.org/10.1111/j.1365-2990.2010.01060.x. Arai T, Hasegawa M, Akiyama H, Ikeda K, Nonaka T, Mori H, et al. TDP-43 is a component ...
Many neurodegenerative diseases including frontotemporal lobar degeneration (FTLD), Lewy body disease (LBD), multiple system atrophy (MSA), etc., show colocalized deposits of TDP-43 and α-synuclein (αS) aggregates. To understand whether these colocaliz