MHC分子提呈抗原肽供T细胞识别 一、T细胞抗原受体（TCR）•结构•基因及多样性形成的机制•与抗原肽/MHC复合物的相互作用 ThestructureoftheTcellreceptor 图1 StructureofTCRissimilartothatofFab 图2 Threesetsofkeyantigen-recognitionreceptorshavesimilaroverallanatomies TheTcellantigenreceptor •...
1. Held, W.& Mariuzza, R. A. Cis interactions of immunoreceptors with MHC andnon-MHC ligands. Nat. Rev. Immunol. 8, 269–278 (2008). 2. Garcia,K. C. et al. An αß T cell receptor structure at 2.5 A and its orientation inthe TCR-MHC complex. Science 274, 209–219 (1996)...
Receptor (TCR) analysis is carried out, harnessing the principles of the 5'RACE technology. This enables the acquisition of full TCR sequences, facilitating comprehensive studies on the impact of Complementarity Determining Regions 1 and 2 (CDR1/2) on Major Histocompatibility Complex (MHC) affinity...
The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation. Nat Commun. 2010; 1 :119.Saline M, Rödström KE, Fischer G, Orekhov VY, Karlsson BG, et al. (2011) The structure of superantigen complexed with TCR and MHC reveals ...
它能识别由MHC分子递呈到宿主细胞表面的来自于外源病原体或由癌变细胞产生的特异抗原。TCR由α链和β链组成。为了应对成千上万的抗原,TCR的α链和β链由DNA的片段重组机理来产生对应的专一性的TCR分子。T 细胞的谱系发育决定完成于胸腺...
However, it is also clear that this high accuracy is driven by the very conserved structure of the MHC, and that the picture is very different when focusing only on the peptide. To further investigate this, we analysed how the pMHC model accuracy depends on the peptide length and the ...
1. Held, W.& Mariuzza, R. A. Cis interactions of immunoreceptors with MHC andnon-MHC ligands. Nat. Rev. Immunol. 8, 269–278 (2008). 2. Garcia,K. C. et al. An αß T cell receptor structure at 2.5 A and its orientation inthe TCR-MHC complex. Science 274, 209–219 (1996)...
(A)黑色素瘤抗原gp100(YLEPGPVTV,黄色棒)呈现在MHC I重链(蓝绿色带)的肽结合槽中。MHC I的肽配位残基以棒状显示。冷冻电镜图的肽区域被描绘成透明的黄色表面。 (B)TCR与gp100/HLA-A2结合的几何构型,其特征在于球面坐标系的旋转角(θ)为93°,倾斜角(Φ)为7°,TCR ...
MHC: Major histocompatibility complex mOVA: Membrane-bound form of chicken ovalbumin NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells NK: Nature killer NS3: Non-structure protein 3 NSCLC: Non-small cell lung carcinoma ...
Discovering antigen-reactive T cell receptors (TCRs) is central to developing effective engineered T cell immunotherapies. However, the conventional technologies for isolating antigen-reactive TCRs (i.e., major histocompatibility complex (MHC) multimer s