MHC分子提呈抗原肽供T细胞识别 一、T细胞抗原受体（TCR）•结构•基因及多样性形成的机制•与抗原肽/MHC复合物的相互作用 ThestructureoftheTcellreceptor 图1 StructureofTCRissimilartothatofFab 图2 Threesetsofkeyantigen-recognitionreceptorshavesimilaroverallanatomies TheTcellantigenreceptor •...
依据已有的研究,preTCR-pΜΗC相互作用是通过preTCRβ与pΜΗC的抗原结合域(α1,α2)。Reinherz/Wang团队首先将preTCR与pΜΗC分别进行简化处理,即仅使用preTCRβ与Kb-t2(鼠源MHC-I的α1,α2),并定点在preTCRβ和Kb-t2上...
The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation. Nat Commun. 2010; 1 :119.Saline M, Rödström KE, Fischer G, Orekhov VY, Karlsson BG, et al. (2011) The structure of superantigen complexed with TCR and MHC reveals ...
However, it is also clear that this high accuracy is driven by the very conserved structure of the MHC, and that the picture is very different when focusing only on the peptide. To further investigate this, we analysed how the pMHC model accuracy depends on the peptide length and the ...
1. Held, W.& Mariuzza, R. A. Cis interactions of immunoreceptors with MHC andnon-MHC ligands. Nat. Rev. Immunol. 8, 269–278 (2008). 2. Garcia,K. C. et al. An αß T cell receptor structure at 2.5 A and its orientation inthe TCR-MHC complex. Science 274, 209–219 (1996)...
通过解析pMHC/TCR复合物的结构,可以分析gp100肽段被包埋在MHC重链中(图2A),而MHC重链被TCR-αβ的CDR区域(complementarity determining regions)所识别,同时与TCR-α亚基(图2B)和β亚基(图2C)存在着许多氨基酸的相互作用。 图2 TCR识别肿瘤相关的gp100/HLA-A2的分子机制 ...
(A)黑色素瘤抗原gp100(YLEPGPVTV,黄色棒)呈现在MHC I重链(蓝绿色带)的肽结合槽中。MHC I的肽配位残基以棒状显示。冷冻电镜图的肽区域被描绘成透明的黄色表面。 (B)TCR与gp100/HLA-A2结合的几何构型,其特征在于球面坐标系的旋转角(θ)为93°,倾斜角(Φ)为7°,TCR ...
1. Held, W.& Mariuzza, R. A. Cis interactions of immunoreceptors with MHC andnon-MHC ligands. Nat. Rev. Immunol. 8, 269–278 (2008). 2. Garcia,K. C. et al. An αß T cell receptor structure at 2.5 A and its orientation inthe TCR-MHC complex. Science 274, 209–219 (1996)...
MHC: Major histocompatibility complex mOVA: Membrane-bound form of chicken ovalbumin NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells NK: Nature killer NS3: Non-structure protein 3 NSCLC: Non-small cell lung carcinoma ...
Receptor (TCR) analysis is carried out, harnessing the principles of the 5'RACE technology. This enables the acquisition of full TCR sequences, facilitating comprehensive studies on the impact of Complementarity Determining Regions 1 and 2 (CDR1/2) on Major Histocompatibility Complex (MHC) affinity...