2002. Distinct structure and signaling potential of the gamma delta TCR complex . Immunity. 16 :827–838 10.1016/S1074-7613(02)00320-5 [ Cross Ref ]Hayes, S. M., and P. E. Love. 2002. Distinct structure and signaling potential of the ␥␦ TCR complex. Immunity 16: 827- 838....
Binding affinities observed between the pHLAs and TCRs are consistent with the results of the cellular killing assay (Table S3 and Supplementary Fig. 2), with the dissociation constant (KD) of the H27-14 TCR/pHLA complex increasing in the following order: A24/Nef134-10(wt) , A24/Nef134...
Hennecke Jens,Wiley DonC.Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivi[J].2002...
In addition, we have crystallized and determined a structure of the SEH–TCR complex at 2.1 Å resolu- tion. Furthermore, a novel approach to study the interface interac- tions between SAgs and its immunoreceptors is by using nuclear magnetic resonance spectroscopy (NMR), as the ...
1992). The Ca2+-dependent and p21ras-dependent signaling pathways that emanate in parallel from the T cell receptor (TCR) are thus reintegrated through NFAT-mediated assembly of a transcriptional complex on lymphokine gene promoters. NFAT and its transcriptional partner bind to composite recognition...
Today's science maps are predominantly generated based on English scholarly data: Techniques and procedures to achieve local and global accuracy of these maps are still being refined, and a visual language to communicate something as abstract and complex as science is still being developed. Yet, ...
Polymorphic major histocompatibility complex (MHC) molecules play a central role in the vertebrate adaptive immune system. By presenting short peptides derived from pathogen-derived proteins, these “classical” MHC molecules can alert the T cell branch of the immune system of infected cells and clear...
12. Structural and magnetic characterization of the di-.mu.(1,3)-azido complex [Cu2(Me5dien)2(N3... Due to their ability to integrate into the host cell's genome, retroviruses represent an optimal basis for the creation of gene therapy vectors. The integr... TR Felthouse,DN Hendrickson...
structure of theSalmonellaTyphimurium FliP–FliQ–FliR complex at 4.2 Å. None of the subunits adopt canonical integral membrane protein topologies, and common helix-turn-helix structural elements allow them to form a helical assembly with 5:4:1 stoichiometry. Fitting of the structure into ...
Crystal morphing with Bayesian optimization for optimizing similarity of XRD pattern to target Despite multiple tries of the evolutionary algorithm, it could fail to create crystal structure to reproduce the target XRD pattern for some complex systems. Particularly, the mean and maximum\({S}_{\cos ...