T cell recognition is highly sensitive and engagement of a single agonist peptide–MHC ligand can be sufficient to induce killing of a target cell. The high sensitivity of TCRs is attributable to the large number of ITAMs in a TCR–CD3 complex and a contribution of endogenous peptide–MHC ...
5. P. Smelty, C. Marchal, R. Renard, L. Sinzelle, N. Pollet, D. Dunon, T. Jaffredo, J.-Y. Sire, J. S. Fellah, Identification of the pre-T-cell receptor alpha chain in nonmammalian vertebrates challenges...
& Xu, C. Ionic protein–lipid interactions at the plasma membrane regulate the structure and function of immunoreceptors. Adv. Immunol. 144, 65–85 (2019). Article CAS PubMed Google Scholar Baeuerle, P. A. et al. Synthetic TRuC receptors engaging the complete T cell receptor for potent...
Both clinical and experimental evidence illustrate that p190 and p210 BCR/ABL oncogenic tyrosine kinases induce resistance to DNA damage and confer an intrinsic genetic instability. Here, we investigated whether BCR/ABL expression could modulate nucleotide excision repair (NER). We found that ectopic ex...
Sign in Structure and Function of TCRαβ Receptors Reference Module in Life Sciences 2024 Purchase options CorporateFor R&D professionals working in corporate organizations. Academic and personalFor academic or personal use only. Looking for a customized option?
T-cell receptors (TCR) andB-cell receptors (BCR)represent distinct classes of immune receptors that exhibit significant differences in both function and structure. As their names suggest, these receptors are present on the surfaces of different cell types. The TCR, a relatively simpler construct, ...
1). We determined a cryoEM structure of the PN45545 TCR-CD3 complex to 3.0 Å resolution (Fig. 1a, b Supplementary Fig. 2a–c, Table 1). Side chain densities were well resolved for most residues in the extracellular (ECD) and transmembrane (TM) domains of each subunit in the ...
[12]ZHAO Q J, JIANG Y, XIANG S X, et al. Engineered TCR-T cell immunotherapy in anticancer precision medicine: pros and cons[J]. Front Immunol, 2021, 12: 658753. [13]HELLMAN L M, FOLEY K C, SINGH N K, et al. Improving T cell ...
They maintained lower expression of exhaustion markers, such as PD-1 and TIM-3, and demonstrated better expansion capabilities compared to conventional CAR-T cells. These benefits were directly linked to the improved IS structure and enhanced CD2 signaling, underscoring the importance of biomimicry in...
1.A nerve ending specialized to sense or receive stimuli. Skin receptors respond to stimuli such as touch and pressure and signal the brain by activating portions of the nervous system. Receptors in the nose detect odors. 2.A cell structure or site that is capable of combining with a hormone...