Exhausted CD8 T (Tex) cells are dysfunctional due to persistent antigen exposure in chronic viral infection and tumor contexts. A stem cell-like Tex (Tex-stem) subset can self-renew and differentiate into terminally exhausted (Tex-term) cells. Here, we show that ectopic Tcf1 expression ...
CD8+T cells. Intravenous vaccination (SNP-IV) induced a higher proportion of TCF1+PD-1+CD8+T cells as compared to subcutaneous immunization (SNP-SC). Single-cell RNA sequencing showed that SNP-IV induced stem-like genes (Tcf7,Slamf6,Xcl1) whereas SNP-SC enriched for effector genes (Gzmb...
在NSCLC和ESCC患者中,PD1-TCF1+CD8+干细胞样记忆T细胞的高表达可能与良好的预后及免疫治疗疗效有关,并且在NSCLC中与肿瘤微环境内TLSs的形成密切相关。 关键词: 肿瘤微环境 / 预后 / 三级淋巴结构 / 干细胞样记忆T细胞 Abstract: Objective To investigate the impact of PD1-TCF1+CD8+ stem-like memory ...
近日,美国埃默里大学国家灵长动物研究中心微生物与免疫学部Mirko Paiardini研究团队在Nature Immunology杂志发表了题为Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and ...
近日,来自瑞士巴塞尔大学的Daniel D. Pinschewer团队等在Immunity杂志上合作发表了一篇题为The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+CD8+T cells in chronic viral infection的文章,他们...
本文利用小鼠模型证明了——肿瘤中存在一群TCF1+ T细胞亚群,PD-1治疗有效主要是通过促进该群细胞发生增殖活化后产生的抗肿瘤作用。 Title: An intra-tumoral niche maintains and differentiates stem-like CD8 T cells Pubication Data: 2019/12/11 Journal: Nature ...
Background Stem-like CD8 T cells that are regulated by the transcription factor TCF1 are key players in the response to immune checkpoint blockers (ICB). Recent findings indicate that the dependance on TCF1+ stem-like T cells for ICB efficacy may not be equal across patients and in ...
In the NSCLC cohort, high levels of PD1-TCF1 CD8 T cells were significantly and positively correlated with the number (P=0.0151) and size (P=0.0007) of TLSs. Conclusion In patients with NSCLC and ESCCs, high PD1-TCF1 CD8 stem-like memory T cell expression indicates improved prognosis ...
3. Silva, J.G., Pais Ferreira, D., Dumez, A., Wyss, T., Veber, R., Danilo, M., Pinschewer, D.D., Charmoy, M., and Held, W. (2023). Emergence and fate of stem cell–like Tcf7+ CD8+ T cells during a primary immune response to viral infection. Sci. Immunol. 8, eadh3...
An intra-tumoral niche maintains and differentiates stem-like CD8 T cells Nature, 576 (2019), pp. 465-470, 10.1038/s41586-019-1836-5 View in ScopusGoogle Scholar 8 S. Kurtulus, A. Madi, G. Escobar, M. Klapholz, J. Nyman, E. Christian, M. Pawlak, D. Dionne, J. Xia, O. Roze...