In the NSCLC cohort, high levels of PD1-TCF1 CD8 T cells were significantly and positively correlated with the number (P=0.0151) and size (P=0.0007) of TLSs. Conclusion In patients with NSCLC and ESCCs, high PD1-TCF1 CD8 stem-like memory T ce...
CD8+T cells. Intravenous vaccination (SNP-IV) induced a higher proportion of TCF1+PD-1+CD8+T cells as compared to subcutaneous immunization (SNP-SC). Single-cell RNA sequencing showed that SNP-IV induced stem-like genes (Tcf7,Slamf6,Xcl1) whereas SNP-SC enriched for effector genes (Gzmb...
近日,美国埃默里大学国家灵长动物研究中心微生物与免疫学部Mirko Paiardini研究团队在Nature Immunology杂志发表了题为Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and ...
在NSCLC和ESCC患者中,PD1-TCF1+CD8+干细胞样记忆T细胞的高表达可能与良好的预后及免疫治疗疗效有关,并且在NSCLC中与肿瘤微环境内TLSs的形成密切相关。 关键词: 肿瘤微环境 / 预后 / 三级淋巴结构 / 干细胞样记忆T细胞 Abstract: Objective To investigate the impact of PD1-TCF1+CD8+ stem-like memory ...
Tcf1 preprograms the mobilization of glycolysis in central memory CD8(+) T cells during recall responses. Nat. Immunol. 23, 386–398 (2022). Article CAS PubMed Google Scholar Shan, Q. et al. Ectopic Tcf1 expression instills a stem-like program in exhausted CD8(+) T cells to enhance...
近日,来自瑞士巴塞尔大学的Daniel D. Pinschewer团队等在Immunity杂志上合作发表了一篇题为The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+CD8+T cells in chronic viral infection的文章,他们...
近日,美国埃默里大学国家灵长动物研究中心微生物与免疫学部Mirko Paiardini研究团队在Nature Immunology杂志发表了题为Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence的研究文章。这项研究通过流式、质谱、scR...
In the NSCLC cohort, high levels of PD1-TCF1 CD8 T cells were significantly and positively correlated with the number (P=0.0151) and size (P=0.0007) of TLSs. Conclusion In patients with NSCLC and ESCCs, high PD1-TCF1 CD8 stem-like memory T cell expression indicates improved prognosis ...
3. Silva, J.G., Pais Ferreira, D., Dumez, A., Wyss, T., Veber, R., Danilo, M., Pinschewer, D.D., Charmoy, M., and Held, W. (2023). Emergence and fate of stem cell–like Tcf7+ CD8+ T cells during a primary immune response to viral infection. Sci. Immunol. 8, eadh3...
1+ cells will give rise to TCF-1+ or TCF-1—cells will be dependent on internal and external signaling. Some studies have shown that both the long (p45) and the short (p33) TCF-1 isoform are expressed by CD8 T cells that will give rise to stem-like CD8 T cells during viral ...