In Type 1 diabetes (T1D), beta cell–specific CD8 T cells destroy insulin-producing beta cells. We followed the fate of beta cell–specific CD8 T cells in non-obese diabetic micethroughout the course of T1D. We identified a stem-like autoimmune progenitor (AP) population in the pancreatic...
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses. Nat. Immunol. 23, 836–847 (2022). Article CAS PubMed Google Scholar McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. CD8 T cell exhaustion during chronic viral infection and cancer. Annu. ...
The common γ-chain cytokines IL-7 and IL-15 have been demonstrated to preferentially generate and expand TSCM-like cells from ex vivo-stimulated, naive human CD8+ T cells22. We therefore sought to determine whether culturing our TCR-engineered CD4+ T cells in IL-7/IL-15, rather than IL...
Recently, a distinct memory T cell subset has been suggested to possess stem cell-like features, sparking the hope to harness its capacity for self-... VR Buchholz,G Patricia,DH Busch - 《Frontiers in Immunology》 被引量: 70发表: 2013年 Migration and differentiation of CD8+ T cells the ...
CSCs, also known as “stem-like cells,”“tumor-initiating cells,” or “immature progenitors of tumor cells,” that are created when epigenetic mutations occur in normal stem cells or progenitor/precursor cells. CSCs are present inside the cancer tissues, and it plays significant role in cancer...
CD8(+) T-memory stem cells maintain the capacity for a cellular immune response against HIV-1 in patients on suppressive antiretroviral therapy Tobin,Stacey,C. - 《Aids》 被引量: 0发表: 2015年 CD8(+) T-memory stem cells maintain the capacity for a cellular immune response against HIV-1 ...
T cells, categorized as tumor-infiltrating lymphocytes (TIL) in tumors in charge of regulating immune responses, consist of subtypes like Th2, and T-reg that could favor tumors, and in some cases could be recruited by turmeric cells, and groups like Th1 and CD8+ T cells act against cancer...
CD8+ cells from a CTL line and CD8+CD137+PD-1+ cells from the patient's BM that were obtained before immunosuppressive therapy were subjected to single-cell sorting using a FACSAria cell sorter (Becton Dickinson) followed by T-cell receptor (TCR) complementary DNA analysis (supplemental Figure...
CD8+ T-memory stem cells maintain the capacity for a cellular immune response against HIV-1 in patients on suppressive antiretroviral therapyAn abstract is unavailable.doi:10.1097/QAD.0000000000000833Tobin SC... SC Tobin - 《Aids》 被引量: 0发表: 2015年 CD8+ T-memory stem cells maintain the ...
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy. Nature 537, 417–421 (2016). CAS PubMed PubMed Central Google Scholar Utzschneider, D. T. et al. T cell factor 1-expressing memory-like CD8+ T cells sustain the immune response to chronic viral infections....