However, stem-like T cells ultimately differentiate into terminally exhausted T cells resulting in relapses and tumor growth. Here, we show that PD1-IL2v targets OVA-specific stem-like T cells, and leads to their expansion and differentiation into a unique population of effector CD8 T cells, ...
在NSCLC和ESCC患者中,PD1-TCF1+CD8+干细胞样记忆T细胞的高表达可能与良好的预后及免疫治疗疗效有关,并且在NSCLC中与肿瘤微环境内TLSs的形成密切相关。 关键词: 肿瘤微环境 / 预后 / 三级淋巴结构 / 干细胞样记忆T细胞 Abstract: Objective To investigate the impact of PD1-TCF1+CD8+ stem-like memory ...
CD8+T cells. Intravenous vaccination (SNP-IV) induced a higher proportion of TCF1+PD-1+CD8+T cells as compared to subcutaneous immunization (SNP-SC). Single-cell RNA sequencing showed that SNP-IV induced stem-like genes (Tcf7,Slamf6,Xcl1) whereas SNP-SC enriched for effector genes (Gzmb...
近日,来自瑞士巴塞尔大学的Daniel D. Pinschewer团队等在Immunity杂志上合作发表了一篇题为The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+CD8+T cells in chronic viral infection的文章,他们...
3. Silva, J.G., Pais Ferreira, D., Dumez, A., Wyss, T., Veber, R., Danilo, M., Pinschewer, D.D., Charmoy, M., and Held, W. (2023). Emergence and fate of stem cell–like Tcf7+ CD8+ T cells during a primary immune response to viral infection. Sci. Immunol. 8, eadh3...
Objective To investigate the impact of PD1-TCF1 CD8 stem-like memory T cells on immunotherapy prognosis and tertiary lymphoid structure in tumors. Methods Pathological tissue sections were collected from 33 patients treated with immunotherapy, 18 cases of NSCLC and 15 cases of ESCC. The expression ...
CD8+ T cell homeostasis is maintained by the cytokines IL-7 and IL-15. Here we show that transcription factors Tcf1 and Lef1 were intrinsically required for homeostatic proliferation of CD8+ T cells. Multiomics analyses showed that Tcf1 recruited the gen
本文利用小鼠模型证明了——肿瘤中存在一群TCF1+ T细胞亚群,PD-1治疗有效主要是通过促进该群细胞发生增殖活化后产生的抗肿瘤作用。 Title: An intra-tumoral niche maintains and differentiates stem-like CD8 T cells Pubication Data: 2019/12/11 Journal: Nature ...
An intra-tumoral niche maintains and differentiates stem-like CD8 T cells Nature, 576 (2019), pp. 465-470, 10.1038/s41586-019-1836-5 View in ScopusGoogle Scholar 8 S. Kurtulus, A. Madi, G. Escobar, M. Klapholz, J. Nyman, E. Christian, M. Pawlak, D. Dionne, J. Xia, O. Roze...
Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy - Scie... Human TCF1+PD-1+cells were detected among tumor-reactive CD8+ Tcells in the blood of melanoma patients and among TILs of primary melan...