In Type 1 diabetes (T1D), beta cell–specific CD8 T cells destroy insulin-producing beta cells. We followed the fate of beta cell–specific CD8 T cells in non-obese diabetic micethroughout the course of T1D. We identified a stem-like autoimmune progenitor (AP) population in the pancreatic...
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy. Nature 537, 417–421 (2016). CAS PubMed PubMed Central Google Scholar Utzschneider, D. T. et al. T cell factor 1-expressing memory-like CD8+ T cells sustain the immune response to chronic viral infections....
Recently, a distinct memory T cell subset has been suggested to possess stem cell-like features, sparking the hope to harness its capacity for self-... VR Buchholz,G Patricia,DH Busch - 《Frontiers in Immunology》 被引量: 70发表: 2013年 Migration and differentiation of CD8+ T cells the ...
T SCM cells are promising candidates for cancer immunotherapies, whereas maintenance of a more stem-cell-like state before transfer is challenging. Here, we established a highly efficient protocol for generating CD8 + T SCM cells from peripheral blood mononuclear cells (PBMCs). The process involved...
The common γ-chain cytokines IL-7 and IL-15 have been demonstrated to preferentially generate and expand TSCM-like cells from ex vivo-stimulated, naive human CD8+ T cells22. We therefore sought to determine whether culturing our TCR-engineered CD4+ T cells in IL-7/IL-15, rather than IL...
HIV-1-specific CD8 T cells can influence HIV-1 disease progression during untreated HIV-1 infection, but the functional and phenotypic properties of HIV-1-specific CD8 T cells in individuals treated with suppressive antiretroviral therapy remain less well understood. Here we show that a subgroup of...
而且,通过immgen数据库,ACKR1的mRNA在多种巨噬细胞亚型中,包括脾CD4+T细胞(CD45+MHC II+CD11c+CD4+)和脾CD8+树突状细胞(CD45+MHC II+CD11c+CD8+)等中均有表达,但是,在腹腔巨噬细胞(F4/ 80+ICAM2+)中并没有表达。作者还通过...
PURPOSE: To evaluate IL13Rα2 as an immunotherapeutic target for eliminating glioma stem-like cancer initiating cells (GSC) of high-grade gliomas, with particular focus on the potential of genetically engineered IL13Rα2-specific primary human CD8(+) CTLs (IL13-zetakine(+) CTL) to target ...
[83]. Intact autocrine EGFR signaling cascade, induced by the redox master regulator Nuclear factor erythroid-derived 2-like 2 (Nrf2/Nfe2l2) through Akt [84], is an important adaptive survival response that contributes to drug resistance in Kras mutant cancer cells [85]. Redox regulation by ...
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses. Nat. Immunol. 23, 836–847 (2022). Article CAS PubMed Google Scholar McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. CD8 T cell exhaustion during chronic viral infection and cancer. Annu. ...