然而，最近的一项研究表明，人类记忆性干细胞样CD8+细胞祖细胞可以转变为功能性干细胞样T(TSTEM)细胞或功能失调的耗竭型前体T细胞 (TPEX)【3】。因此，调节分化标志物的表达可能对于生成具有可在体内持续存在的功能性记忆CAR-T细胞至关重要。近日，来自澳大利亚彼得·麦卡伦癌症中心的Paul J. Neeson团队在Science ...
Expression of ID3 itself enables Tpex cells to sustain T cell responses in chronic infection or cancer, whereas loss of ID3 results in impaired maintenance of CD8 T cell immunity. Furthermore, we demonstrate that interleukin-1 (IL-1) family members, including IL-36尾 and IL-18, promote the...
(naive/central memory cells); EM CD8+ T cells; “early-activation” CD8+ T cells (intermediate profile between naive-like and EM); CD8+ precursor-exhausted cells (Tpex, equal to stem-like resource cells); CD8+ terminally-exhausted (Tex) effector cells; CD4+ Th1-like cells, CD4+ ...
An MHC-restricted antibody-based chimeric antigen receptor requires TCR-like affinity to maintain antigen specificity. Mol Ther Oncolytics. 2016;3:1–9. Article PubMed Google Scholar Lim WA, June CH. The principles of engineering immune cells to treat cancer. Cell. 2017;168:724–40. Article ...
A subset of stem/progenitor markers correlated positively with CD8+ T-cell markers (ex. CD10, CD44), while others correlated positively with B-cell markers (ex. SSEA-3/SSEA-4). Interestingly, a different set of stem/progenitor markers showed the strongest positive correlations with the ...
10.1097/01.TP.0000082540.43730.80. Article PubMed Google Scholar Prevosto C, Zancolli M, Canevali P, Zocchi MR, Poggi A: Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction. Haematologica. 2007, 92: 881-888. 10.3324/haematol.11240. Article CAS...
In this study, we examined the expression profile of HLA molecules on the surface of human ES cells, EB cells and blast-like cells. We demonstrated extremely low levels of HLA-A2 expression in the undifferentiated H9 human ES cell line, somewhat elevated HLA expression on the EB cells, and...
Originally derived from bone marrow [1, 2], MSCs and MSC-like cells have been identified to exist in and can be isolated from a large number of adult tissues, where they are postulated to carry out the function of replacing and regenerating local cells that are lost to normal tissue turn...
MSCs and EC can exchange mitochondria through tunneling nanotube (TNT)-like structures at the basal level in a bidirectional manner. The mitochondrial exchange occurs with the oxygen–glucose deprivation/reoxygenation stress-induced mitochondrial transfer from MSCs to injured EC, resulting in the rescue ...
This approach, using a monoclonal or small molecule, could be combined with depleting antibodies directed against T cells and natural killer cells as well as B cells, many of which exist and some of which, like anti-CD52/alemtuzumab, are in widespread clinical use (95,96). Combined, this ...