are indicated with BB) compound can be used as molecular probe and namely accumulate in brain for Protein tau to be imaged.HIGUCHI MakotoSUHARA TetsuyaMARUYAMA MasahiroCHO MeieiSHIMADA Hitoshi
为深入揭示Tau蛋白乙酰化在创伤性脑损伤及AD病理中的作用，近日，来自美国凯斯西储大学、克利夫兰医学中心等多个单位的研究人员在Cell杂志在线发表了题为 Reducing tau acetylation is neuroprotective in brain injury 的研究论文，通过一些列生物化学研究手段，揭示了Tau蛋白乙酰化在创伤性脑损伤和AD发病中的病理生理学机...
Source:Tokyo Medical and Dental University Tau and PQBP1: Protein Interaction Induces Inflammation in the Brain Reference: Jin, M., Shiwaku, H., Tanaka, H. et al. Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation. Nat Commun 12, 6565 (2021). https...
MSUT2和PABPNI通常会密切配合以调节大脑中tau的生物学特性。相关研究结果近期发表在Science Translational Medicine期刊上,论文标题为“Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain”。 小鼠大脑中的tau蛋白缠结物,图片来自UW Medicine。 论文通讯...
8月29日,Nature杂志在线发表了剑桥大学MRC实验室Michel Goedert组与Sjors H. W. Scheres组合作完成的一篇题为Structures of filaments from Pick’s disease reveal a novel tau protein fold论文,阐述了皮克病的tau蛋白纤维丝的冷冻电镜(Cryo-EM)结构,将为皮克病的治疗提供新的方案和见解。
[10] Kontsekova E, Zilka N, Kovacech B, Skrabana R, Novak M. Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer's disease. Alzheimers Res Ther. 2014;6(4):45. Published 2014 Aug 1. doi...
Tau and PQBP1: Protein Interaction Induces Inflammation in the Brain Reference: Jin, M., Shiwaku, H., Tanaka, H. et al. Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation. Nat Commun 12, 6565 (2021). doi.org/10.1038/s41467- ...
1.Renaud La Joie et al.Prospective longitudinal atrophy in Alzheimer's disease correlates with the intensity and topography of baseline tau-PET. Science Translational Medicine, 2020, doi:10.1126/scitranslmed.aau5732. 2.Alzheimer 'tau' protein far surpasses amyloid in predicting toll on brain tissue...
3. Marc Aurel Busche, Bradley T Hyman, et al. Synergy between amyloid-β and tau in Alzheimer's disease. Nat Neurosci. 2020 Oct;23(10):1183-1193. 4. Jwa-Jin Kim, Minho Moon, et al. Vitamin D-binding protein-loaded PLGA nanoparticles suppress Alzheimer's disease-related pathology in 5X...
But the exact role of the tau protein in these diseases has remained a mystery. 为了帮助解决这个谜题,李甘博士和她的同事们创建了一个全面的图谱,称为 Tau 蛋白相互作用体,它绘制了在实验室中生长的人类神经元中所有 Tau 蛋白与其他蛋白质的相互作用。甘博士指出,tau 蛋白处于神经退化的中心,了解它如何...