We adapted the tau and kappa paradigms to an interception task by presenting four stimuli (visually or auditorily) one after another on four locations, from left to right, with constant spatial and temporal int
Health Your Microbiome Shapes Your Psychedelic Trip This Experience Could Teach Us About Consciousness AI Will Double Human Lifespan By 2030, CEO Claims Every Human Body Gives Off an Invisible Glow These Cells Can Defy the Rules of Reproduction ...
Neuroimmunology is one of the fastest-growing fields in the life sciences, and for good reason; it fills the gap between two principal systems of the organism, the nervous system and the immune system. Although both systems affect each other through bidi
they saw that some hadP. gingivalisand protein accumulations, but at low levels. We already know that amyloid and tau can accumulate in the brain for 10 or 20 years before Alzheimer’s symptoms begin. This, says the team, shows thatP. gingivalisdoesn’t get into the brain as a ...
In addition, during REM sleep we see the Glymphatic System in full swing (this is the system that removes Alzheimer’s causing proteins called Beta-Amyloid and Tau), so this part too, helps with resilience. What is sleep debt and how does it impact our mental health and cognitive ...
Hsp90 is an essential molecular chaperone responsible for the folding and activation of hundreds of ‘client’ proteins, including the glucocorticoid receptor (GR). Previously, we revealed that Hsp70 and Hsp90 remodel the conformation of GR to regulate l
Many attempts to develop drugs to treat Alzheimer's have focused on beta amyloid itself without notable success. Improving the “wash cycle” in the brain might clear away not just beta amyloid but other toxins as well, such as tau, a protein that has been found tangled in...
While there is now considerable evidence that the microbiota–gut–brain axis plays an important role in mental and cognitive health, human clinical studies have as yet provided few clear answers to one burning question. How? How does the gut microbiota influence brain development [13] and functio...
How does protein misfolding result in Alzheimer's disease? What is the pathogenesis of Alzheimer's disease? How does chronic stress affect the brain? What is the Alzheimer's disease process? How do neurological disorders and Alzheimer's disease affect cognitive ability? What is Alzheimer's diseas...
“I loop” of the protein, a domain between transmembrane regions 8 and 9. Patients with point mutations tend to have later onset disease with milder (though still very severe) symptoms, suggesting a partial loss of function. Consistent with this, studies in patient lymphocytes determined that ...