Sign up for alerts RSS feed nature nature neuroscience articles article Article Open access Published: 21 November 2024 Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease Stephanie L. Fowler, Tiana S. Behr, Emir Turkes, Darragh P. O’Brien, Paula Maglio...
Spatial decrease of synaptic density in amnestic mild cognitive impairment follows the tau build-up patternALZHEIMERS-DISEASENATIONAL INSTITUTEGUIDELINESDEPOSITIONNext to amyloid and tau, synaptic loss is a key pathological hallmark in Alzheimer's disease, closely related to cognitive dysfunction and ...
Upregulation of Na,Cl--Coupled Betaine/ γ-Amino-Butyric Acid Transporter BGT1 by Tau Tubulin Kinase 2. Background/Aims: The serine/threonine kinase Tau-tubulin-kinase 2 (TTBK2) is expressed in various tissues including kidney, liver and brain. Loss of functi... Almilaji,Ahmad,Munoz,......
The retina, a posterior neurosensory eye tissue, is an extension of the brain and shares many structural and functional features. Recent studies have revealed the genetic basis for eye-brain connections, suggesting bidirectional genetic causal links between retinal structures and neurological disorders, ...
68, 69 Thus, preventing the buildup of aggregates by small-molecule inhibitors could be a promising strategy in the treatment of tauopathies. The non-neuroleptic phenothiazine methylene blue, which penetrates the BBB, and its desmethyl derivatives have been described to inhibit tau aggregation, with...
Amyloid-beta and tau proteins have long been associated with Alzheimer’s disease. The pathological buildup of these proteins leads to cognitive decline in people with the disease. How it does that, though, remains poorly understood. A new study from the labs of Sylvain Baillet at The ...
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in the nucleus, as well as interactions with mitochondria, the plasma membrane and the Actin cytoskeleton [3]. In the adult human brain alternative splicing of a single-copy gene generates six Tau isoforms that differ by the absence or presence of one or two inserts in the amino-terminal ...
Article Open access 13 November 2023 Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer’s disease Article 06 May 2021 Cell type-specific roles of APOE4 in Alzheimer disease Article 08 January 2024 Main...
[70], tau accumulation rates were found to be rather uniform across brain regions, arguing against the notion that the build-up of tau pathology progresses in a stepwise manner, as suggested by histopathological studies. However, the discrepancy between histopathological and in vivo PET findings ...