8月29日,Nature杂志在线发表了剑桥大学MRC实验室Michel Goedert组与Sjors H. W. Scheres组合作完成的一篇题为Structures of filaments from Pick’s disease reveal a novel tau protein fold论文,阐述了皮克病的tau蛋白纤维丝的冷冻电镜(Cryo-EM)结构,将为皮克病的治疗提供新的方案和见解。 在正常成年人脑中,有...
In the previous year, a paired helical filament (PHF) protein had been identified in neurofibrillary tangles in the brains of individuals with Alzheimer disease (AD), but it was not until 1986 that the PHF protein and tau were discovered to be one and the same. In the AD brain, tau was...
Brain PathologyGoedert M. Tau protein and neurodegeneration [ J ]. Semin Cell Dev Biol, 2004, 15( 1 ) :45 -49.GOEDERT, M. Tau protein and neurodegeneration. Semin Cell Dev Biol, 1, 45-49, (2004)Goedert M. (2004). Tau protein and neurodegeneration. Semin Cell Dev Biol 15: 45-49....
3. Goedert, M., & Spillantini, M. G. (2019). Ordered assembly of tau protein and neurodegeneration. In Tau Biology (pp. 3 - 21). Springer.
Tau protein and neurodegeneration Tau protein is the major component of the intracellular filamentous deposits that define a number of neurodegenerative diseases. They include the largely s... M Goedert - 《Seminars in Cell & Developmental Biology》 被引量: 381发表: 2004年 Axonal transport, tau ...
tau蛋白病理,即tau蛋白的聚集和缠结的形成,是AD和原发性tau蛋白疾病的共同机制,如皮质基底神经变性(corticobasal neurodegeneration,CBD)和进展性核上麻痹(supranuclear palsy,PSP)。 尽管,在原发性tau蛋白疾病中,tau蛋白病理是以丝状或是以更加弥散的形式呈现于神经胶质细胞中,但是,tau蛋白病理主要存在于AD神经元中。
including tauopathy and TDP-43 proteinopathy.Tauopathy is characterized by the presence of tau-positive protein aggregates in the affected brain regions.In tauopathy patients,a large number of mutations have been identified that either alter the tau protein property or affect tau pre-mRNA splicing...
为深入揭示Tau蛋白乙酰化在创伤性脑损伤及AD病理中的作用，近日，来自美国凯斯西储大学、克利夫兰医学中心等多个单位的研究人员在Cell杂志在线发表了题为 Reducing tau acetylation is neuroprotective in brain injury 的研究论文，通过一些列生物化学研究手段，揭示了Tau蛋白乙酰化在创伤性脑损伤和AD发病中的病理生理学...
Structurally, tau is a natively unfolded protein, is highly soluble and shows little tendency for aggregation. However, tau aggregation is characteristic of several neurodegenerative diseases known as tauopathies. The mechanisms underlying tau pathology and tau-mediated neurodegeneration are debated, but ...
1. Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer’s Disease, Wu XL et al, Chin Med J (Engl). 2017 Dec 20;130(24):2978-2990 2. Phosphorylation and Dephosphorylation of Tau Protein During Synthetic Torpor, Luppi M et al, Front. Neuroanat., ...