The assembly of tau into filaments defines tauopathies, a group of neurodegenerative diseases including Alzheimer's disease (AD), Pick's disease (PiD), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP). The seeded aggregation of tau has been modeled in cell culture using ...
Using brain-derived tau oligomers (BDTOs) from AD, PSP, and DLB patients, we investigated neuronal internalization mechanisms of BDTOs, including the heparan sulfate proteoglycan (HSPG)-mediated pathway, clathrin-mediated pathway, and caveolae-mediated pathway. Here, we demonstrated that the HSPG-...
However, whether human brain‐derived EVs induce tau pathology has not yet been characterized in the mouse brain. Here, we assess the mechanisms of disease spread after intrahippocampal injection of human brain‐derived EVs into the aged mouse model.doi:10.1002/alz.037316...
Brain-derived TAU protein kinase antibody|脑源性TAU蛋白激酶抗体 基本信息 更多信息 中文名称: 脑源性TAU蛋白激酶抗体 中文同义词: 脑源性TAU蛋白激酶抗体 英文名称: Brain-derived TAU protein kinase antibody 英文同义词: CAS号: 分子式: 分子量: 0 EINECS号: 信息错误报告 您的Email: 按国家浏览...
TauAmyloid betaDementiaProteins implicated in neurodegenerative conditions such as Alzheimer's disease (AD) and Dementia with Lewy Bodies (DLB) have been identified in bodily fluids encased in extracellular vesicles called exosomes. Whether exosomes found in DLB patients can transmit pathology is not ...
TOXICITY AND PROPAGATION OF TBI BRAIN-DERIVED SOLUBLE TAU STRAINSdoi:10.1016/j.jalz.2018.06.022Alice BittarTasneem HassanNemil BhattSalome McAllenRakez KayedAlzheimer's and Dementia
Differential levels of α-synuclein, β-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease Ikeuchi T: Differential levels of alpha-synuclein, beta- amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease... ...
Our study relates to a series of previous publications which aimed to reproduce ex vivo fibril structures from tau, α-synuclein, Aβ or SAA protein under controlled conditions inside a test tube.13, 14, 19, 23 Although high resolution structural data were not always reported, some studies des...
The aims of this study were to 1) determine if the protein content of brain-derived exosomes from patients diagnosed with AD or DLB contain Aβ, tau and/or α- syn over non-diseased individuals and 2) test the hy- pothesis that brain derived exosomes from DLB patients can seed and ...
Neonatal bilirubin-induced neurotoxicity was validated by significantly decreased serum BDNF, brain BDNF, and serum S100B, along with significantly increased serum tau protein (p<0.05). PHZ-induced hemolytic hyperbilirubinemia significantly decreased serum BDNF, brain BDNF, and PLC/IP3/Ca2+pathway ...