Background Recent studies have suggested that plasma p-tau biomarkers are associated with cross-sectional brain amyloid(Aβ) rather than tau tangle pathology. However, it is still unclear if plasma tau biomarkers are closely related to changes in AD pathophysiology over time. In this work, we ...
We recently presented the promising blood-based neurodegeneration biomarker brain-derived tau (BD-tau) that showed higher levels in biomarker-confirmed AD versus non-AD dementia and unaffected controls, including in a cohort with autopsy-verification of diagnosis and in memory clinic cohorts with large...
Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer’s disease Article Open access 04 April 2024 Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer’s trial selection and disease monitoring Article Open access 01 December 2022 Main ...
"Stem cell derived phenotypic human neuromuscular junction model for dose response evaluation of therapeutics". "Vitamin D3 decreases glycolysis and invasiveness, and increases cellular stiffness in breast cancer cells". "Boric Acid as an Efficient Agent for the Control of Polydopamine Self-Assembly and...
Specifically, serum brain-derived tau was specifically increased in AD and was able to differentiate AD from bvFTD (AUC = 0.93) [28]. Further investigations highlighted distinctive variations in the abundance of the third and fourth repeats in the microtubule-binding region (MTBR) of tau in...
Plasma p-tau217 was more strongly correlated with brain β-amyloid and paired helical filament tau (PHFtau) tangles than p-tau181. Both p-tau markers were associated with greater odds of AD, but p-tau217 had higher accuracy (area under the ROC curve (AUC): 0.83) than p-tau181 (AUC:...
Plasma phosphorylated tau 217 in preclinical Alzheimer’s disease. Brain Commun. 2023;5(2):fcad057. doi:10.1093/braincomms/fcad057PubMedGoogle ScholarCrossref 26. Johnson SC, Koscik RL, Jonaitis EM, et al. The Wisconsin Registry for Alzheimer’s Prevention: a review of ...
Longitudinal trajectory of plasma p-tau217 in CU A- subjects according to ApoE4 status. Interaction plot derived from LMM of plasma p-tau217 in healthy controls. Estimates come from the interaction effects of the best model for plasma p-tau217. Predicted plasma p-tau217 values are on the ...
4,5 Leptin, one of the major adipocyte-derived hormones or adipokines, is produced primarily by adipose tissue and plays an important role in regulating appetite, body weight, and energy metabolism.6 Leptin is known to be associated with brain physiology through both its regulation of systemic ...
Conclusion Plasma p-tau217 is an accurate biomarker of both tau and Aβ pathological brain changes in DS that could facilitate inclusion of individuals with DS in future AD clinical trials, especially when combined with age as a covariate....