Brain Stemtau Proteins睡眠呼吸暂停综合征脑干TAU 蛋白质类Background: Recently, it has been reported that neuronal plasticity in the brainstem arousal pathway is related to the sudden infant death syndrome (SIDS). tau protein may contribute to axonal development and neural plasticity; therefore, the ...
参考文献(上下滑动阅读) [1]Boland, B., W.H. Yu, O. Corti, et al. Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing. Nat Rev Drug Discov, 2018, 17(9): 660-688 [2]Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau deriv...
图2 各组大鼠海马区突触蛋白的表达和树突棘密度Figure 2 The expression of synaptic protein and spine density in the hippocampal of the rats in each group. A:comparison of PSD93 and PSD95 protein levels in the hippocampal of r...
近日,德国神经退行性疾病研究中心和马克思·普朗克多学科科学研究所的Markus Zweckstetter课题组与马克斯·普朗克分子细胞生物学与遗传学研究所Alf Honigmann课题组合作在Nature Communications杂志上发表题为“ Multivalent Tau/PSD-95 interactions arrest in vitro condensates and clusters mimicking the postsynaptic density”...
Tau aggregation is a defining histopathological feature of Alzheimer's disease and other tauopathies. However, the cellular mechanisms involved in tau propagation remain unclear. Here, we performed an unbiased quantitative proteomic study to identify proteins that specifically interact with this tau seed....
(Eea 1) in a manner that depended on FcR interaction indicating uptake through the endolysosomal pathway (Fig.4I). As lysosomal proteolytic cleavage of internalised proteins is dependent on acidification of the vesicles to create a pH optimum for lysosomal proteases, we tested if pharmacological ...
BrainAnimalsHumansAlzheimer DiseaseTauopathiestau ProteinsFemaleMaleResearchers from Japan and the USA have developed a new PET radioligand that can be used to detect tau deposits in the brains of living individuals. This approach could provide important insights into an aspect of the Alzheimer disease ...
However, little is known about the long-term stability of these biomarker proteins in plasma samples stored at –80°C. We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort. Plasma samples from 229 cognitively unimpaired individuals, ...
Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer brain and the possible mechanism To understand the possible mechanism for the abnormal hyperphosphorylation and elevation of NF in AD brain, we treated human SY5Y neuroblastoma cell with protein phosphatase(PP)-2A and PP-1 inhibit...
Why the... Johnston,A J. - 《Journal of Cell Biology》 被引量: 3655发表: 1998年 Accumulation of Mutant Huntingtin Fragments in Aggresome-like Inclusion Bodies as a Result of Insufficient Protein Degradation The huntingtin exon 1 proteins with a polyglutamine repeat in the pathological range (51...