2. M. Goedert, Tau filaments in neurodegenerative diseases,FEBS Lett, 2018, 592(14): 2383-2391. 3. B. Ghetti, A.L. Oblak, B.F. Boeve, K.A. Johnson, B.C. Dickerson, M. Goedert, Invited review: Frontotemp...
为深入揭示Tau蛋白乙酰化在创伤性脑损伤及AD病理中的作用，近日，来自美国凯斯西储大学、克利夫兰医学中心等多个单位的研究人员在Cell杂志在线发表了题为 Reducing tau acetylation is neuroprotective in brain injury 的研究论文，通过一些列生物化学研究手段，揭示了Tau蛋白乙酰化在创伤性脑损伤和AD发病中的病理生理学机...
Source:Tokyo Medical and Dental University Tau and PQBP1: Protein Interaction Induces Inflammation in the Brain Reference: Jin, M., Shiwaku, H., Tanaka, H. et al. Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation. Nat Commun 12, 6565 (2021). https...
Fig. 5 Brain levels (normalized for total protein content) of N-123 (a), N-224 (b) fragments,and t-tau (c) in AD and controls and in AD over Braak stages III–VI (d, e, f) (lines representing the median, bars representing interquartile range) 实验发现,抗tau224蛋白抗体可以染色神...
MSUT2和PABPNI通常会密切配合以调节大脑中tau的生物学特性。相关研究结果近期发表在Science Translational Medicine期刊上,论文标题为“Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain”。
Tau protein phosphorylation in diverse brain areas of normal and CRH deficient mice: up-regulation by stress. Cell. Mol. Neurobiol. 32, 837-845.Tau Protein Phosphorylation in Diverse Brain Areas of Normal and CRH Deficient Mice: Up-Regulation by Stress[J] . Peter Filipcik,Petr Novak,Boris ...
8月29日,Nature杂志在线发表了剑桥大学MRC实验室Michel Goedert组与Sjors H. W. Scheres组合作完成的一篇题为Structures of filaments from Pick’s disease reveal a novel tau protein fold论文,阐述了皮克病的tau蛋白纤维丝的冷冻电镜(Cryo-EM)结构,将为皮克病的治疗提供新的方案和见解。
2.Alzheimer 'tau' protein far surpasses amyloid in predicting toll on brain tissue https://medicalxpress.com/news/2020-01-alzheimer-tau-protein-surpasses-amyloid.html 版权声明 本网站所有注明“来源:生物谷”或“来源:bioon”的文字、图片和音视频资料,版权均属于生物谷网站所有。非经授权,任何媒体、网站...
[10] Kontsekova E, Zilka N, Kovacech B, Skrabana R, Novak M. Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer's disease. Alzheimers Res Ther. 2014;6(4):45. Published 2014 Aug 1. doi...
一篇在线发表在《大脑》(Brain)杂志上的论文[1],确定了 tau 蛋白与 RNA 的相互作用是阿尔茨海默病和其他失智症发展的关键阶段,RNA 是我们所有细胞器的蓝图分子。Kraemer 和他在美国退伍军人事务部(U.S. Department of Veterans Affairs)和西雅图华盛顿大学(University of Washington)医学系的同事报告了这一发现。