Targeting Epigenetics in Lung Cancerdoi:10.1101/CSHPERSPECT.A038000Yvonne L. ChaoChad V. PecotCold Spring Harbor Laboratory Press
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These data support additional investigations pertaining to the epigenetics of lung cancer, and the evaluation of chromatin remodeling agents for the treatment and prevention of this disease. 展开 关键词: Receptors Thromboxane A2 Prostaglandin H2/drug effects/physiology Research Support Non-U.S. Gov't ...
As another important part of epigenetics, non-coding RNAs (ncRNAs) have been recognized as key regulators of virtually every cellular process which is closely associated with gene expression. In addition, they act as oncogenes or tumor suppressors in various cancers as well.68Generally, non-coding...
BetaPowered by GenAIQuestions answered in this article Keywords Abbreviations 1. Introduction 2. KMTs and their Roles in Lung Cancer 3. KDMs and their Roles in Lung Cancer 4. Histone Arginine Methylation/Demethylation in Lung Cancer 5. Representative Histone Methyltransferase/Demethylase Inhibitors 6....
The emerging role of epigenetics in inflammation and Immunometabolism Trends Endocrinol. Metab., 27 (11) (2016), pp. 782-795 Google Scholar [18] G.D. Norata, et al. The cellular and molecular basis of translational Immunometabolism Immunity, 43 (3) (2015), pp. 421-434 Google Scholar [...
The role of epigenetics in myeloid cells and therapy resistance Myeloid cells exhibit a high degree of plasticity, characterized by their ability to deviate from typical differentiation pathways and generate diverse tolerogenic myeloid cell states within the TME. A substantial component of this plasticity...
2) was generated and potently degraded BRD4 in lung cancer NCI-H661 cells [45]. CRBN-based PROTACs Thalidomide and its analogs (Fig. 1b) are common ligands of E3 ligase CRBN. ARV-825 (Fig. 2), consisting of pomalidomide and BRD4 inhibitor OTX015, induced degradation of BRD4 and ...
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In this Review, we discuss recent developments for each epigenetic drug class and their implications for therapy, as well as highlight new insights into the role of epigenetics in cancer. This is a preview of subscription content, access via your institution Access options Access Nature and 54...