T-cell receptor articles from across Nature Portfolio Atom RSS Feed T-cell receptors (TCRs) recognize small protein fragments (peptides) that are displayed on the surface of antigen-presenting cells. Each T cel
Relating T cell receptor (TCR) sequencing to antigen specificity is a challenge especially when TCR specificity is unclear. Here the authors use a low dimensional generative approach to model TCR sequence similarity and to associate TCR sequences with the same specificity. ...
T cell surface glycoproteins recognize antibodies. The differentiation of the T cells begins with the differentiation of their receptors. At the beginning, the TCR is double negative, i.e., it is CD4 CD8 . The disulphide-linked heterodimers have α and β or γ and δ chains, containing ...
CAR是Chimeric Antigen Receptor的缩写,翻译过来即是“嵌合抗原受体”,它是一种人为设计的、帮助T细胞识别肿瘤的装置。 正常情况下,T细胞执行杀伤功能前,需要一套复杂的识别机制,来验证所清除的“目标”不是我们的“自己人”。这种识别过程主要包括了TCR(T Cell Receptor,即...
The T cell receptor (TCR) is a T cell surface structure that is comprised of a disulfide-linked heterodimer of highly variable α and β chains expressed at the cell membrane as a complex with the invariant CD3 chains. Most T cells that bear this type of receptor are termed αβ T cells...
‹T-Cell Receptor (TCR) TCR Cell Signaling Pathway T-cells are a subset of lymphocytes that play a large role in the immune response. The TCR (T-cell receptor) is a complex of integral membrane proteins that participate in the activation of T-cells in ...
‹T-Cell Receptor (TCR) TCR 细胞信号传导通路 T 细胞是在免疫反应中发挥重大作用的淋巴细胞的亚群。TCR (T-细胞受体) 是一种跨膜蛋白复合体,在抗原呈递应答反应中参与 T 细胞的活化。MHC (主要组织相容性复合体) 分子对抗原细胞上的 TCR 刺激。与 TCR 结合可启动阳性和阴性级联...
T细胞抗原受体(T cell receptor,TCR)(名词解释) 相关知识点: 试题来源: 解析 是T细胞特异性识别和结合抗原肽-MHC分子的分子结构,通常与CD3分子呈复合物形式存在于T细胞表面。大多数T细胞的TCR由α和β肽链组成,少数T细胞的TCR由γ和δ肽链组成。反馈 收藏 ...
Single-cell analysis T-cell receptor repertoire Complementarity-determining region 3 TCR alpha TCR beta TCR diversity Unbiased repertoire Paired analysis Clonotype Techniques Immunofluorescence Nested PCR Agarose Gel Electrophoresis Data analysis Light Microscopy RNA Extraction Freeze-thaw Method Reverse...
T细胞受体工程T细胞(engineered T cell receptor-T cell,TCR-T)疗法和嵌合抗原受体T细胞(chimeric antigens receptor-T cell,CAR-T)疗法是将T细胞特异性重定向到肿瘤抗原的两种主要方法[1],作为最新、最有效的两种免疫治疗技术,近年来受到了广泛关注。在临床试验中,...