STEM cell transplantationRNA analysisIn contrast to the curative effect of allogenic stem cell transplantation in acute myeloid leukemia via T cell activity, only modest responses are achieved with checkpoint-blockade therapy, which might be explained by T cell phenotypes and T cell receptor (TCR) ...
STEM cell transplantationIMMUNITYIMMUNE responseTRANSPLANTATION of organs, tissues, etc.NUCLEOTIDE sequencingCytomegalovirus (CMV) infection is a major complication during allogeneic stem cell transplantation (allo-SCT). However, mechanisms of adaptive immunity that drive this remain unclear. To define early ...
The T cell receptor (TCR) repertoire has the potential to provide rich and dynamic information on the status of adaptive immunity in an individual during pathological processes, such as cancer, and following therapeutic interventions. However, obtaining an accurate description of the repertoire poses ...
T cell receptorphytohaemagglutininflow cytometrypolymerase chain reactionSUMMARYMilogen stimulation of T cells in vitro has been employed in the analysis of the T cell antigen receptor (TCR) repertoire and as a method of generating T cell lines and clones. It has been suspected for some time ...
TCR在衰老中的变化 除了胸腺之外,T 细胞受体 (T Cell Receptor,TCR) 在T细胞的发育和衰老过程中也发生了显著的变化。TCR 是由受体亚基 (TCR αβ或γδ) 和 CD3 亚基 (CD3γ, δ, ε和ζ) 组成的复合受体[24,25]。在经典 T 细胞的发育过程中,一系...
T‐cell receptorT‐cell receptor sequencingT‐cell repertoireThe adaptive immune system arose 600 million years ago in a cold‐blooded fish. Over countless generations, our antecedents' tunned the function of the T cell receptor (TCR). The TCR system is arguably the most complex known to ...
T-cells are lymphocytes that have a unique, high-affinity, specific T-cell receptor (TCR) to a single antigenic peptide (epitope). From:Seminars in Immunology,2018 Also in subject areas: Agricultural and Biological Sciences Biochemistry, Genetics and Molecular Biology ...
The T-cell receptor (TCR), located on the surface of T cells, is responsible for the recognition of the antigen-major histocompatibility complex, leading to the initiation of an inflammatory response. Analysing the TCR repertoire may help to gain a better understanding of the immune system featur...
The unbiased, paired analysis of T-cell receptor (TCR) α- and β-chain usage at the single-cell level provides a valuable window of understanding into the TCR repertoire and the nature of the immune response. Earlier technologies for TCR repertoire …more The unbiased, paired analysis of T...
这是一篇粉丝来稿,该文献是2021发表在《Nature communication》的《Single cell T cell landscape and T cell receptor repertoire profifiling of AML in context of PD-1 blockade therapy》,文章介绍了在经过PD-1免疫治疗前后AML(急性髓细胞性白血病)病人T亚群和占比的变化,提出可以使用免疫治疗前T细胞克隆型和GZMK...