Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes ...
T-cell receptor articles from across Nature Portfolio Atom RSS Feed T-cell receptors (TCRs) recognize small protein fragments (peptides) that are displayed on the surface of antigen-presenting cells. Each T cell expresses a unique TCR that is generated by randomly assorting genes. This ensures...
上期文章《 细胞免疫研究的核心通路——T cell receptor signaling pathway(上) 》中,介绍了TCR信号通路的结构、相关膜表面蛋白及通路主要过程,今天继续分享TCR信号通路的关键调节结点、T细胞发育过程中的TCR信号通路调节、CD28超家族的共刺激/抑制作用。 一、TCR信号通路的关键调节结点 1.1 LCK结点的调节 酪氨酸激酶LCK...
T-cells are a subset of lymphocytes that play a large role in the immune response. The TCR (T-cell receptor) is a complex of integral membrane proteins that participate in the activation of T-cells in response to an antigen. Stimulation of TCR is triggered ...
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其表面存在的T细胞受体(T cell receptor, TCR)能够识别主要组织相容性复合体(major histocompatibility complex, MHC)呈递的抗原多肽,并将抗原结合信号转换为胞内酪氨酸磷酸化信号,引发下游信号通路来激活T细胞。在临床上,T细胞受体工程化T细胞(T cell receptor-engineered...
T CELL RECEPTOR SEQUENCINGThe present invention relates to methods for preparing complementary deoxyribonucleic acid (cDNA) molecules comprising T cell receptor (TCR) sequences and determining the nucleic acid sequence of those TCRs.
第二种可导致效应 T 细胞死亡的机制由肿瘤坏死因子受体超家族成员(如 Fas(CD95))所介导的信号激活,其能够激活细胞凋亡的外在(或死亡受体)途径(extrinsic (or death receptor) pathway of apoptosis,见图 9.45)。Fas 信号与细胞凋亡途径的偶联受到细胞半胱天冬酶 8 样抑制蛋白(c-FLIP,Cellular FLICE (FADD-like...
T细胞抗原受体(T cell receptor,TCR)(名词解释) 相关知识点: 试题来源: 解析 是T细胞特异性识别和结合抗原肽-MHC分子的分子结构,通常与CD3分子呈复合物形式存在于T细胞表面。大多数T细胞的TCR由α和β肽链组成,少数T细胞的TCR由γ和δ肽链组成。反馈 收藏 ...
T CELL RECEPTORS The T cell receptor (TCR) is a T cell surface structure that is comprised of a disulfide-linked heterodimer of highly variable α and β chains expressed at the cell membrane as a complex with the invariant CD3 chains. Most T cells that bear this type of receptor are ter...