7、记忆T细胞(Memory T cell,Tm),有记忆特异性抗原刺激的作用。T细胞在体内存活的时间可数月至数年。其记忆细胞存活的时间则更长。 其中,Th细胞又被称为CD4+细胞,因为其在表面表达CD4(cluster of differentiation 4)。通过与MHCⅡ(主要组织相容性复合体,major histocompatibility complex)递呈的多肽抗原反应被激活。
Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade can reinvigorate TEX cells, but reinvigoration is not durable. A major unanswere
Immunology & Cell BiologyKallies A. Distinct regulation of effector and memory T-cell differentiation. Immunol Cell Biol. 2008; 86 (4):325–32.Kallies A (2008) Distinct regulation of effector and memory T-cell differentiation. Immunol Cell Biol 86(4):325–332. : 10.1038/icb....
The stem cell model of immunologic memory proposes that a single memory lymphocyte re-encountering antigen gives rise to one set of progeny capable of terminal differentiation and another capable of self-renewal138. In a single-cell adoptive-transfer method, TCMcells have exhibited self-renewal and ...
The number of naïve and memory T cells in the periphery is determined by the rate of new T-cell generation in the thymus, and proliferation, differentiation, and death of existing T cells. It has been known for some time that when T cells are severely depleted, residual T cells undergo...
但是这些标签总是静止的,而T细胞是在免疫过程中定义的,他们的名字很清楚:Naïve / Memory Cells / T Helper Cell / Antigen-Specific T Cell Exhaustion / Regulatory T Cells /γδ T Cells,虽然也有叫做CD4T / CD8T 的。细胞的名称就像代码中的变量名一样,应该是有意义的,而不只是个标签。
Synonyms Memory CD8 + and CD4 + T cells; Memory T lymphocytes Definition T cell memory arises from a complex molecular process in which a na茂ve T lymphocyte encounters its cognate antigen, expands in numbers, and acquires long-lived and functionally improved features. This process results in ...
T-cell memory differentiation: insights from transcriptional signatures and epigenetics. A critical component of vaccine design is to generate and maintain antigen-specific memory lymphocytes of sufficient quantity and quality to give the host ... B Youngblood,JS Hale,R Ahmed - 《Immunology》 被引量...
mTOR signaling in CD8+ T-cell activation andmemory differentiation CD8+T细胞对获得性免疫至关重要。它们在最初的反应中清除病原体,形成记忆细胞,提供即时和强大的保护,防止病原体再次攻击。CD8+T细胞对急性感染的反应动力学可简化为三个...
T Cell Memory Differentiation in Mouse and Man Author links open overlay panelBeatrice Bolinger 1 7 8, Stuart Sims 1 8, Leo Swadling 1, Geraldine O’Hara 1, Catherine de Lara 1, Dilair Baban 2, Natasha Saghal 2, Lian Ni Lee 1, Emanuele Marchi 1, Mark Davis 3, Evan Newell 4, Stef...