Here, we discuss the signals required for commitment to this programme of development and the factors that might influence its progression. Models of the pathways of effector and memory T-cell differentiation are discussed, and we highlight the implications of this new understanding for the ...
In response to pathogen infection, naive T lymphocytes undergo activation and proliferation, giving rise to progeny with effector and memory fates that are able to mediate immediate and long-term protection. In this Review we use the terms 'effector' and 'memory' to refer to antigen-experienced ...
Immunological memory is a cardinal feature of adaptive immunity and an important goal of vaccination strategies. Here we highlight advances in the understanding of the diverse T lymphocyte subsets that provide acute and long-term protection from infectio
VACCINES: EFFECTOR AND MEMORY T-CELL DIFFERENTIATION: IMPLICATIONS FOR VACCINE DEVELOPMENT. Effector and memory T-cell differentiation: implications for vaccine developmentRecent work shows that after stimulation with antigen, CD4+ and CD8+ T cells... Kaech,Susan,M.,... - 《Nature Reviews ...
The precise pathways of memory T-cell differentiation are incompletely understood. Here we exploit transgenic mice expressing fluorescent cell cycle indicators to longitudinally track the division dynamics of individual CD8+ T cells. During influenza vir
Mcl-1 overexpression failed to affect CD8 T-cell expansion, contraction or the magnitude of CD8 T-cell memory. Strikingly, high Mcl-1 levels enhanced mTOR phosphorylation and augmented the differentiation of terminal effector cells and effector memory CD8 T cells to the detriment of poly-cytokine-...
The smallest unit: effector and memory CD8(+) T cell differentiation on the single cell level . Front Immunol (2013) 4 ( 31 ):31.10.3389/fimmu... VR Buchholz,G Patricia,DH Busch - 《Frontiers in Immunology》 被引量: 70发表: 2013年 Memory CD8+ T cell differentiation: initial antigen...
Effector and memory T-cell differentiation: implications for vaccine development Nat. Rev. Immunol., 2 (2002), pp. 251-262 CrossrefView in ScopusGoogle Scholar Kaech et al., 2003 S.M. Kaech, J.T. Tan, E.J. Wherry, B.T. Konieczny, C.D. Surh, R. Ahmed Selective expression of...
T cell differentiation into lung-homing T effector cells•CD11bhi RDCs stimulate CD8+ T cell differentiation into central memory-like T effector cells•CD103+ RDCs express elevated CD24 compared to CD11bhi RDCs•RDC CD24 modulates CD8+ T cell activation by presenting HMGB1 to T cell RAGE...
ARTICLES Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin Andrew M Intlekofer1, Naofumi Takemoto1, E John Wherry4,8, Sarah A Longworth1, John T Northrup1, Vikram R Palanivel1, Alan C Mullen1, Christopher R Gasink1, Susan M Kaech4,8, Joseph D Miller4, ...