It is interesting to speculate as to the developmental relationship between central-memory and effector-memory subsets. When restimulated in vitro, CD62LhiCCR7+ memory CD4+ T cells became CD62LloCCR7−, which suggests that central memory cells can give rise to effector T cells or, perhaps,...
Th1/Th2 cellsCytokinesMemoryRodentMemory and effector T cells modulate subsequently primed T cell responses to the same antigen. However, little is known about the impact of pre-existing memory and effector T cell immunity on subsequently primed immune responses to unrelated antigens. Here, we ...
Immunological memory is an important characteristic of adaptive immune response and elucidation of its cellular basis is critical for vaccine exploration and disease prevention. Recent studies have shown that memory T cells could be divided into central memory T cells and effector memory T cells, which...
T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T CellsT-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T CellsMemory T cells are composed of effector, central, and memory stem cel...
Glycosylation changes on surface molecules of T cells affect cell trafcking and function and may be useful in discriminating between naive, effector, and memory T cells. To analyze oligosaccharide structures on T cells activated in vivo, we examined alterations in sialic acid residues on T cells ...
Engaging the power of the patient's own immune system to actively seek out and destroy transformed cells holds great promise for cancer therapy. Tumor vaccines offer the potential for preventing cancer in high-risk individuals, preventing disease relapse after diagnosis and initial therapy, and shifti...
There is now considerable evidence suggesting that CD8+ T cells are able to generate effector but not functional memory T cells following pathogenic infections in the absence of CD4+ T cells. We show that following transplantation of allogeneic skin, in the absence of CD4+ T cells, CD8+ T ce...
The memory T cells which can induce the secondary immune responses play an important role in human immune system. 记忆T细胞作为人体免疫系统中的一个组成部分,在免疫应答中发挥着至关重要的作用,因此利用抗独特型抗体制备诱导产生记忆T细胞的疫苗是免疫学领域的一个重要方向。 更多例句>> 5...
Human Vγ9/Vδ2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1) The killer cell lectin-like receptor G1 (KLRG1) is expressed in natural killer (NK) cells and effector memory alphabeta T cells. Gammadelta T cells represe... Matthias Eberl,Rosel Engel,Silk...
In addition to effector and memory CD8(+) T cells, populations described as exhausted, anergic, senescent, and regulatory CD8(+) T cells have been observed in clinical and basic studies of antitumor immune responses. In the context of antitumor immunity, these CD8(+) T cell subsets remain ...