Effector memory T cells are associated with atherosclerosis in humans and animal models. J Am Heart Assoc 2012;1:27e41.Ammirati E, Cianflone D, Vecchio V, Banfi M, Vermi A, De Metrio M, Grigore L, et al. , Effector Memory T cells Are Associated With Atherosclerosis in Humans and ...
Unfortunately, donor T cells can attack nonmalignant host tissues and cause graft-versus-host disease (GVHD). We previously reported that donor CD4+ effector memory T cells (TEMs) do not cause GVHD but transfer functional T-cell memory. In the present work, we demonstrate in an MHC-...
Live imaging of effector memory T cells at a site of inflammation -a Kv1.3 blocker suppresses T cell motility.We used two-photon imaging to visualize the homing of CD4+CCR7- CD45RC- GFP-labeled ovalbumin-specific effector memory T (TEM) cells to the ears of rats undergoing a DTH reaction...
Expansion of circulating CD28 T-cells reminiscent of effector memory T-cells (TEM) has been reported in Wegener's granulomatosis (WG) recently. To investigate the role of TEM in WG, we analyzed the expression of the activating NK-receptor NKG2D and its ligand MIC on circulating TEM and in ...
Immunological memory is an important characteristic of adaptive immune response and elucidation of its cellular basis is critical for vaccine exploration and disease prevention. Recent studies have shown that memory T cells could be divided into central memory T cells and effector memory T cells, which...
Central memory T (Tcm) cells, which express CD62L and CCR7, tend to localize to lymphoid tissues and are capable of robust recall proliferation and interleukin-2 (IL-2) production, whereas effector-memory T (Tem) cells, characterized by lack of CD62L and CCR7 expression, are prevalent at...
memory T cell (Tcm) responses41, associated with durable immune-mediated control in the setting of natural HIV infection42. In the context of vaccination, central memory cells can quickly mount greater anamnestic effector responses than those of Tem, which have a limited proliferative capacity and ...
They are memory-like cells, generated in vivo from CCR6-CD25+ T cells after the encounter of antigen. As conventional CD25- effector-memory T cells, they have a high turnover rate and, in contrast to CCR6- Treg cells, they respond rapidly to restimulation in vitro with up-regulation of...
Progressive loss of effector functions, especially IFN‐γ secreting capability, in effector memory CD8+ T (CD8+ TEM) cells plays a crucial role in asthma worsening. However, the mechanisms of CD8+ TEM cell dysfunction rema...
Abstract Human CD4+ T cells can be classified as either naïve, central memory (TCM), or effector memory (TEM) cells. To identify the CD4+ T cell subsets... Fumichika Matsuki and Jun Saegusa and Yoshiaki Miyamoto and Kenta Misaki and Shunichi Kumagai and Akio Morinobu - 《Biochemical &...