Immunological memory is an important characteristic of adaptive immune response and elucidation of its cellular basis is critical for vaccine exploration and disease prevention. Recent studies have shown that memory T cells could be divided into central memory T cells and effector memory T cells, which...
Memory T cells can be classified as central memory (TCM, CD45RAnegCCR7+), effector memory (TEM, CD45RAnegCCR7neg), and terminally differentiated cells (TTD, CD45RA+CCR7neg) with different homing and effector capacities. In 101 healthy subjects aged from 5 to 96 years, distinct dynamics ...
These re-directed T cells specifically lysed NY-ESO-1(157-165)/HLA-A*02:01-positive cells and secreted IFN gamma. A total of 40% of CCR7(-) re-directed T cells had an effector memory phenotype and 5% a central memory phenotype. Based on CCR7 cell sorting, effector and memory CAR-...
These re-directed T cells specifically lysed NY-ESO-1157–165/HLA-A*02:01-positive cells and secreted IFNγ. A total of 40% of CCR7− re-directed T cells had an effector memory phenotype and 5% a central memory phenotype. Based on CCR7 cell sorting, effector and memory CAR-positive T...
CentralRoberts AD, Ely KH, Woodland DL (2005) “Differential contributions of central and effector memory T cells to recall responses.” J Exp Med 202 (1):123–133Roberts AD, Ely KH, Woodland DL (2005) Differential contributions of central and effector memory T...
Memory T cells can be classified as central memory (T CM, CD45RA negCCR7 +), effector memory (T EM, CD45RA negCCR7 neg), and terminally differentiated cells (T TD, CD45RA +CCR7 neg) with different homing and effector capacities. In 101 healthy subjects aged from 5 to 96 years, dis...
While most antigen-specific cells die following pathogen clearance, some cells survive to form a diverse and long-lived memory compartment that protects against secondary infection. The potent protective capacity of central memory CD8+ T cells (Tcm) depends on their stem-cell-like properties to ...
Purpose The profile of central (=T-CM) and effector (=T-EM) memory CD4(+) T cell subsets and the possible role as surrogate markers of protection is studied in the volunteers with history of cutaneous leishmaniasis (HCL).Methods Profile of T cell subsets based on CCR7/CD45RA expressions...
N. Dysfunctional memory CD8+ T cells after priming in the absence of the cell cycle regulator E2F4. Cell. Immunol. 257, 44–54 (2009). Article CAS PubMed PubMed Central Google Scholar Utzschneider, D. T. et al. Active maintenance of T cell memory in acute and chronic viral infection...
Human CD4+ T cells can be classified as either naïve, central memory (TCM), or effector memory (TEM) cells. To identify the CD4+ T cell subsets most important in the pathogenesis of rheumatoid arthritis (RA), we phenotypically defined human CD4+ T cells as functionally distinct subsets, ...