T Cell Memory One important function of T cells (and B cells, as discussed later) is the formation of long-lasting memory after the initial exposure to a pathogen. Following massive expansion of pathogen-specific T cells during infection, most T cells die once the infection has resolved. Howe...
Cell DifferentiationThe importance of in the generation of CD8(+) T cells in vivo is not well defined. We report here that was dynamically regulated in virus-specific CD8(+) T cells during of with . In contrast to the current paradigm, decreased in activated proliferating effector CD8(+) T...
Three models have been proposed to describe memory T cell formation (Fig.1). In the first model, Tscm, Tcm and Tem cells differentiate from naïve T cells in a stepwise manner as they progress toward a more terminally differentiated phenotype (Sallusto et al.,1999) (Fig.1A). A study i...
CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against pathogens and malignancies, and the molecular processes that lead to TRM cell formation are therefore of substantial biomedical interest. Prior work has demonstrated that signals present in the inflamed tissue mic...
Recent work shows that after stimulation with antigen, CD4+ and CD8+ T cells embark on a programme of proliferation that is closely linked with the acquisition of effector functions and leads ultimately to memory-cell formation. Here, we discuss the signals required for commitment to this programm...
Analyses of liver and splenic PbT-I cells 34–36 days after vaccination, once viral antigen was cleared from the liver (Figure S4), revealed effects of both adjuvant and viral components on memory T cell formation (Figures 4B, 4D, and 4E). In the absence of the rAAV component, Clec9A-...
Surviving the crash: transitioning from effector to memory CD8+ T cell One outcome of infection is the formation of long-lived immunological memory, which provides durable protection from symptomatic re-infection. In response ... LM D'Cruz,MP Rubinstein,AW Goldrath 被引量: 0发表: 2019年 CCR7...
Wakim, L. M. et al. The molecular signature of tissue resident memory CD8 T cells isolated from the brain.J. Immunol.189, 3462–3471 (2012). CASPubMedGoogle Scholar Laidlaw, B. J. et al. CD4+T cell help guides formation of CD103+lung-resident memory CD8+T cells during influenza vi...
3月27日发表于Nature杂志的一项研究中(“Formation of memory assemblies through the DNA-sensing TLR9 pathway”),研究人员揭示了一个关于长期记忆形成的令人惊奇的发现:神经元(nerve cells)在记忆形成过程中,其DNA会经历断裂和修复的循环,这...
Central memory T cell (TCMcell). A type of memory T cell that expresses L-selectin and CC-chemokine receptor 7 (CCR7) and that can recirculate through secondary lymphoid organs. TCMcells can produce interleukin-2 and can proliferate extensively in response to restimulation. ...