In vitro differentiation of murine Sca-1+Lin- cells into myeloid, B cell and T cell lineages. Stem Cells 1996;14:412-418. [PubMed: 8843542]Ito M, Anan K, Misawa M et al. (1996) In vitro differentiation of murine Sca-1+Lin- cells into myeloid, B cell, and T cell lineages. Stem...
Neoplastic differentiation: interaction of simian virus 40 and polyoma virus with murine teratocarcinoma cells in vitro. The host-virus interactions of Simian virus 40 (SV40) and polyoma virus (Py) with cell lines established from a teratocarcinoma were studied. The cells uti... DE Swartzend...
Tube morphogenesis is essential for internal-organ development, yet the mechanisms regulating tube shape remain unknown. Here, we show that different mechanisms regulate the length and diameter of the murine trachea. First, we found that trachea developm
We investigated the use of differentiation therapy as a method of purging bone marrow (BM) of leukemic cells in ex vivo murine BM expansion cultures (delta-cultures). In clonal cultures and in suspension cultures a combination of the differentiation-inducing agents granulocyte colony-stimulating facto...
cell differentiation-associated geneTagln2, according to the SCENIC (single-cell regulatory network inference and clustering) analysis (Fig.2b, c). This indicated that cluster 12 cells presented a closer relationship with secondary P-TGCs. In addition, secondary P-TGCs were more abundant at E8.5...
Another important parameter that must be considered, particularly because of decreased proliferation and the propensity towards senescence observed in cells from aged donors, is the effect of cell passage on the differentiation capability of adult MSCs. BMSCs largely lose their in vitro differentiation ...
invade into multi-organs of SLE patients and contribute to loss of tolerance. In addition, DN T cells promote B cell differentiation, induce the production of autoantibodies as well as the secretion of pro-inflammatory cytokines including IFN-γ and IL-17 [14,15]. Th17 cells, a T cell subs...
For polarization assays, FACS-sorted nave CD4+ T cells were TCR-activated for 7 days under Th1/2/17/Treg-differentiation conditions. BALB/c mice were administered 60 mg/kg pevonedistat SC twice weekly for 3 weeks and T cell populations were analyzed by flow cytometry. Results: In vitro ...
BALB/c mice were administered 60 mg/kg pevonedistat SC twice weekly for 3 weeks and T cell populations were analyzed by flow cytometry. Results: In vitro treatment of T cells with pevonedistat led to rapid reduction in neddylated cullins and stabilization of pIκBα. NAE inhibition did ...
In contrast, community composition was characterised by a memory of disturbance comparable to that observed in studies using antibiotics as disturbing agents (De La Cochetie`re et al., 2005, Dethlefsen and Relman, 2011). Upregulation of pro-inflammatory cytokines, inflamed tissue and a ...