近期多项报道指出,免疫检查点抑制治疗可以促进前体细胞的分化,也可以这样理解,也就是前体细胞的水平与免疫检查点抑制治疗的疗效息息相关。前体细胞通常表达有TCF1(transcription factor T cell factor 1 ),这也与SIY特异性细胞所表达的分子标签相符合。 因为SIIN诱导CD8+T细胞水平比SIY更高,作者猜测这一竞争结果很...
T cell factor 1 (TCF-1)T cell factor 1 (TCF is a transcription factor (TF) of the canonical Wnt signaling pathway that encoded by the Tcf7. The crucial role of TCFin T cell development and memory formation has been widely recognized. Recent studies have demonstrated that exhausted CD8+ ...
在T细胞中, β-catenin 有一个重要的DNA结合共因子,T细胞转录因子1(transcription factor T cell factor 1, TCF-1)【6】。之前有研究表明TCF-1的缺失会导致胸腺调节T细胞的增加【7】,因此,TCF-1在调节T细胞中可能具有重要的功能。 为了确定TCF-1在Treg中的功能, 2021年8月12日,Khashayarsha Khazaie团队(共同...
在T细胞中, β-catenin 有一个重要的DNA结合共因子,T细胞转录因子1(transcription factor T cell factor 1, TCF-1)【6】。之前有研究表明TCF-1的缺失会导致胸腺调节T细胞的增加【7】,因此,TCF-1在调节T细胞中可能具有重要的功能。...
7 Utzschneider, D. T. et al. T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections. Immunity 45, 415-427, doi:10.1016/j.immuni.2016.07.021 (2016).8 Wu, T. et al. The TCF1-Bcl6 axis counteracts type I interferon to ...
近期多项报道指出,免疫检查点抑制治疗可以促进前体细胞的分化,也可以这样理解,也就是前体细胞的水平与免疫检查点抑制治疗的疗效息息相关。前体细胞通常表达有TCF1(transcription factor T cell factor 1 ),这也与SIY特异性细胞所表达的分子标签...
TCF 1 (T-cell Factor 1) (Biotin) 中文名: 中文别名: CBNumber: CB04969259 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商1 TCF 1 (T-cell Factor 1) (Biotin)化学性质 安全信息 TCF 1 (T-cell Factor 1) (Biotin)性质、用途与生产工艺 ...
T cell factor 1 (TCF1) is required for memory and stem-like CD8+ T cell functions. How TCF1 partners with other transcription factors to regulate transcription remains unclear. Here we show that negative elongation factor (NELF), an RNA polymerase II (Po
T-cell factor 4 (TCF4) is an important transcription factor of the Wnt signaling system. -catenin, an upstream protein of TCF4, accumulates in the cytoplasm, then translocates to the nucleus to activate the -catenin/T-cell factor/lymphoid enhancer factor (TCF/LEF) transcriptional machinery and ...
T细胞主要是由骨髓来源的共同淋巴祖细胞(common lymphoid progenitor cell,CLP)在胸腺微环境的作用下发育而来。部分CLP离开骨髓随血液循环进入胸腺后称之为ETP,该类细胞群在胸腺中具有向T细胞,自然杀伤(natural killer, NK)细胞,髓系细胞分化的潜能,而无向B细胞分化的能力。随后在以T细胞因子(T cell factor,TCF)-7,...