在T细胞中, β-catenin 有一个重要的DNA结合共因子,T细胞转录因子1(transcription factor T cell factor 1, TCF-1)【6】。之前有研究表明TCF-1的缺失会导致胸腺调节T细胞的增加【7】,因此,TCF-1在调节T细胞中可能具有重要的功能。 为了确定TCF-1在Treg中的功能, 2021年8月12日,Khashayarsha Khazaie团队(共同...
在T细胞中, β-catenin 有一个重要的DNA结合共因子,T细胞转录因子1(transcription factor T cell factor 1, TCF-1)【6】。之前有研究表明TCF-1的缺失会导致胸腺调节T细胞的增加【7】,因此,TCF-1在调节T细胞中可能具有重要的功能。...
前体细胞通常表达有TCF1(transcription factor T cell factor 1 ),这也与SIY特异性细胞所表达的分子标签相符合。 因为SIIN诱导CD8+T细胞水平比SIY更高,作者猜测这一竞争结果很可能与SIY所诱导的TCF+前体细胞相关。为了证实这一猜测,作者分别构建了单独表达SIY和SIIN的小鼠(LucSIIN 和LucSIY ),并发现,仅SIY并不能...
TCF 1 (T-cell Factor 1) (Biotin) 中文名: 中文别名: CBNumber: CB04969259 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商1 TCF 1 (T-cell Factor 1) (Biotin)化学性质 安全信息 TCF 1 (T-cell Factor 1) (Biotin)性质、用途与生产工艺 ...
近期多项报道指出,免疫检查点抑制治疗可以促进前体细胞的分化,也可以这样理解,也就是前体细胞的水平与免疫检查点抑制治疗的疗效息息相关。前体细胞通常表达有TCF1(transcription factor T cell factor 1 ),这也与SIY特异性细胞所表达的分子标签相符合。 因为SIIN诱导CD8+T细胞水平比SIY更高,作者猜测这一竞争结果很...
近期多项报道指出,免疫检查点抑制治疗可以促进前体细胞的分化,也可以这样理解,也就是前体细胞的水平与免疫检查点抑制治疗的疗效息息相关。前体细胞通常表达有TCF1(transcription factor T cell factor 1 ),这也与SIY特异性细胞所表达的分子标签...
Accordingly, TCF1-deficient mice are hyperresponsive to experimental autoimmune encephalomyelitis. Thus, TCF1, a constitutively expressed T cell-specific transcription factor, is a critical negative regulator of the inflammatory potential of TCR-activated T cells and autoimmunity.Qing...
7 Utzschneider, D. T. et al. T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections. Immunity 45, 415-427, doi:10.1016/j.immuni.2016.07.021 (2016).8 Wu, T. et al. The TCF1-Bcl6 axis counteracts type I interferon to ...
T cell factor 1 (TCF1) is required for memory and stem-like CD8+ T cell functions. How TCF1 partners with other transcription factors to regulate transcription remains unclear. Here we show that negative elongation factor (NELF), an RNA polymerase II (Po
Here we report that ILC2 development required T cell factor 1 (TCF-1, the product of the Tcf7 gene), a transcription factor also implicated in T cell lineage specification. Tcf7−/− mice lack ILC2, and were unable to mount ILC2-mediated innate type 2 immune responses. Forced ...