产品名称:Trans-acting T-cell-specific transcription factor GATA-3 ELISA Kit 检测范围: 保存条件:2-8℃低温保存 保质期:6个月,所有试剂盒均提供批次。 试剂盒成分:酶标板,试剂,标准品等。 操作步骤 1.标准品的稀释:本试剂盒提供原倍标准品一支,用户可按照下列图表在小试管中进行稀释。
LT is a member of the tumor necrosis factor (TNF) superfamily that has major role in lymphoid organogenesis6,7. LT has two subunits (LTα and LTβ) and is found in two distinct forms: soluble homotrimer of LTα (LTα3) that binds TNF receptors, and membrane-bound heterotrimer (LTα...
PFN, porfrin; Gzm, Granzyme B; IFN, interferon; TNF, tumor necrosis factor; MHC, major histocompatibility complex.Adapted from “T Cell Activation in Cancer” by BioRender.com (2021). Retrieved from https://app.biorender.com/biorender-templates. By recognizing the target antigen by the TCRs...
Hepatitis C virus (HCV) infection is a common etiologic factor of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). The World Health Organization’s Global Hepatitis Report estimates that about 71 million individuals are currently infected with HCV worldwide1. The majority of in...
FOXO1是一种转录因子(transcription factor),能够调控多种基因的表达,从而影响细胞的行为和功能。最近的研究发现,通过增加FOXO1蛋白的表达量,可以使CAR T细胞表现出类似于干细胞的特性,这一点在斯坦福大学和宾夕法尼亚大学的团队研究中得到了验证。 研...
Elisa assays of cell culture supernatants from CD8+ T on MMP9 stimulation showed MMP9 suppressed the secretion of granzyme B, IFN-γ, and tumour necrosis factor α (TNF α) (figure 3H). To delineate the role of MMP9 in CD8+ T cell migration, tumour-conditioned medium (CM) was added ...
Tumor necrosis factor XRT: Radiation therapy Klebanoff CA, Khong HT, Antony PA, Palmer DC, Restifo NP. Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy. Trends Immunol. 2005;26:111–7. ...
For CAR structures, the selection of the costimulatory domain is a critical factor to explore. Although CAR T-cells with CD28 or 4-1BB have similar clinical efficacy, they differ in kinetics and phenotype [26]. scRNA-seq showed that they had distinct transcriptional expression profiles, whether...
Both baseline and poststimulation datasets were gated on CD3+events to identify T cells (Extended Data Fig.1g,h), which were assessed for the expression of a panel of effector molecules, consisting of the cytokines interferon-γ (IFN-γ), tumor necrosis factor (TNF), interleukin (IL)-2, ...
The precise pathways of memory T-cell differentiation are incompletely understood. Here we exploit transgenic mice expressing fluorescent cell cycle indicators to longitudinally track the division dynamics of individual CD8+ T cells. During influenza vir