T-cell dependent 专业医学词典 依赖性T-细胞,T细胞依赖的 与"T-cell dependent"相近的词条 ... T-cell antigen receptor site T cell area T cell B cell interaction T cell chronic lymphocytic(leukemia) T cell-conditioned medium T-cell dependent t-cell dependent antigen、T-cell-dependent antigen T-...
Few studies have considered the impact of the human lung mucosa (alveolar lining fluid (ALF)), which modifies the() cell wall, revealing alternate antigenic epitopes on the bacterium surface that alter its pathogenicity. We hypothesized that ALF-induced modification of BCG would induce better ...
CD8+ T cells control tumors but inevitably become dysfunctional in the tumor microenvironment. Here, we show that sodium chloride (NaCl) counteracts T cell dysfunction to promote cancer regression. NaCl supplementation during CD8+ T cell culture induced effector differentiation, IFN-γ production...
5. Cao W, # Liu J,# Jiang Z, Tao Y, Wang H, Li J, Ni J,* and Wu X*. Tumor suppressor Adenomatous Polyposis Coli sustains dendritic cell tolerance through IL-10 in a β-catenin dependent manner. Journal of Immunology. 2023 Mar 31: ji2300046. doi: 10.4049/jimmunol.2300046. PMI...
10. G. Germano, et al. CD4 T cell-dependent rejection of beta-2 microglobulin null mismatch repair-deficient tumors Cancer Discov., 11 (2021), pp. 1844-1859 在抗体圈微信公众号回复“JPM23”可下载60家药企PPT合集。 —END— 严正声明
Tcell death and malfunction, thereby fueling tumor progression. Mechanistically, taurine deficiency in CD8+Tcells increases ER stress, promotingATF4transcription in a PERK-JAK1-STAT3 signaling-dependent manner. Increased ATF4 transactivates multiple immune checkpoint genes and induces Tcell exhaustion. In...
4a), we reasoned that CLTCH129>Q-specific CD4+ T cell-mediated protection may be dependent on their role as helper cells for CD8+ T cells19. Consistent with this, depletion of CD8+ T cells before the transfer of CD4+ T cells and tumor inoculation prevented tumor rejection (Fig. 4f). ...
利妥昔单抗能特异性结合B细胞上的CD20抗原 ,通过抗体依赖细胞介导的细胞毒作用(ADCC)、抗体依赖性细胞吞噬 (antibody⁃dependent cell⁃mediated phagocytosis,ADCP)和补体依赖性细胞毒作用(complement⁃ dependent cytotoxicity,CDC)等途径杀伤CD20...
Toll-like receptors (TLRs) are located either on the cell surface or intracellularly in endosomes and their activation normally contributes to the induction of protective immune responses. However, in cancer their activation by endogenous ligands can mod
2021年5月20日,中科院北京基因组研究所韩大力团队和清华大学免疫研究所徐萌团队合作在Cancer Cell上发表了题为The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth的研究论文,揭示了特定肿瘤相关巨噬细胞亚群通过表观转录组层面调控...