根据所传递的细胞产物,ACT大致可分为肿瘤浸润淋巴细胞(tumor infiltrating lymphocyte,TIL)、嵌合抗原受体 T 细胞(chimeric antigen receptor T cell,CAR-T)和 T 细胞受体工程化 T 细胞(T cell receptor engineered T cell,TCR-T)3 ...
Boosting γδ T cell-mediated antibody-dependent cellular cytotoxicity by PD-1 blockade in follicular lymphomaPD-1follicular lymphomaanti-CD20 MAbs3D modelγδ T cellsFollicular lymphoma (FL) is a common non Hodgkin's lymphoma subtype in which immune escape mechanisms are implicated in resistance to...
利妥昔单抗能特异性结合B细胞上的CD20抗原 ,通过抗体依赖细胞介导的细胞毒作用(ADCC)、抗体依赖性细胞吞噬 (antibody⁃dependent cell⁃mediated phagocytosis,ADCP)和补体依赖性细胞毒作用(complement⁃ dependent cytotoxicity,CDC)等途径杀伤CD20...
Ligation of Fas/Fas-L results in target cell apoptosis via a caspase-dependent pathway. (C) In addition to these direct killing mechanisms, CTLs can also induce indirect or “bystander” tumor cell death by secreting cytokines that work at a distance. TNFα sec...
Ligation of Fas/Fas-L results in target cell apoptosis via a caspase-dependent pathway. (C) In addition to these direct killing mechanisms, CTLs can also induce indirect or “bystander” tumor cell death by secreting cytokines that work at a distance. TNFα secr...
After 60 years of intense fundamental research into T cell-mediated cytotoxicity, we have gained a detailed knowledge of the cells involved, specific recognition mechanisms and post-recognition perforin–granzyme-based and FAS-based molecular mechanisms. What could not be anticipated at the outset was...
Microenvironmental oxygen pressure orchestrates an anti- and pro-tumoral γδ T cell equilibrium via tumor-derived exosomes. Oncogene 38, 2830–2843 (2018). Article PubMed CAS Google Scholar Rossi, C. et al. Boosting γδ T cell-mediated antibody-dependent cellular cytotoxicity by PD-1 ...
T cells constitute the cellular arm of the adaptive immune system and their activation is dependent on signals from three different receptor types: the T-cell antigen receptors, costimulatory receptors, and cytokine receptors. The intracellular signals transduced by each of these activated receptors are...
Rader RK, Kahn LE, Anderson GD, Martin CL, Chinn KS & Gregory SA (1996). T cell activation is regulated by voltage-dependent and calcium-activated potassium channels. J Immunol 156, 1425–1430. Schindl R, Kahr H, Graz I, Groschner K & Romanin C (2002). Store depletion-activated CaT...
Ligation of Fas/Fas-L results in target cell apoptosis via a caspase-dependent pathway. (C) In addition to these direct killing mechanisms, CTLs can also induce indirect or “bystander” tumor cell death by secreting cytokines that work at a distance. TNFα secr...