The pathogenic free-living amoeba Naegleria fowleri inflicts extensive CPE on neuroblastoma cells by two mechanisms, troglocytosis and contact-dependent lysis, that are not mutually exclusive (16). ...Berke,G.T-cell mediated cytotoxicity. Current Opinion in Immunology . 1991
1974 . Sensitivity of cytotoxic T cells to T cell-mediated cytotoxicity . Nature (Lond.) . 252 :81 .Golstein, P. 1974. Sensitivity of cytotoxic T-cells to cell-mediated cytotoxicity. Nature (Lond.), 252:81-83.GOLDSTEIN P. (1974) Sensitivity of cytotoxic T cells to T cell-mediated ...
After 60 years of intense fundamental research into T cell-mediated cytotoxicity, we have gained a detailed knowledge of the cells involved, specific recognition mechanisms and post-recognition perforin–granzyme-based and FAS-based molecular mechanisms. What could not be anticipated at the outset was...
However, in the absence of cytotoxic T cells, CD4+ T cell-mediated cytotoxicity is important for control of EBV infection. Evidence for a selective dysregulation of EBNA1-specific T cell responses, such as disrupted antibody-dependent cellular cytotoxicity of EBV-infected cells and defective T ...
Cytotoxicity assays Cytolytic activity is the major function of CD8+ T cells and several assays are used to measure efficacy [9]. Chromium (51Cr) release cytotoxicity assay: This assay is considered the gold standard for assessing cell-mediated cytotoxicity. It rel...
Cytotoxicity assays Cytolytic activity is the major function of CD8+ T cells and several assays are used to measure efficacy [9]. Chromium (51Cr) release cytotoxicity assay: This assay is considered the gold standard for assessing cell-mediated cytotoxicity. It rel...
Xu Y, Yang Z, Horan L H, et al. A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta[1]TCR signaling to facilitate T-cell cytotoxicity with low cytokine release[J/OL]. Cell Discov...
The immunosuppressive role and mechanism of MUC21 were validated using NK and T cell mediated cytotoxicity assays. Bioinformatics tools were employed to assess the clinical implications of mucin-21 (MUC21) in cancer cell immunity. Results Our genetic screens revealed that MUC21 expression on cancer ...
First-generation CAR T-cells contained an intracellular domain from the TCR CD3 ζ-chain that induced T cell cytotoxicity effect against targeted cancer cells but could not to promote CAR T cell expansion in vivo following reinfusion; on the other hand, second- and third-generation CAR T ...
Sykulev Y, Joo M, Vturina I, et al. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response[J]. Immunity, 1996, 4(6): 565-571. Harris D T, Hager M V, Smith S N, et al. Comparison of...