T-cytotoxic cells (TC cells) are a group of cells that receive “help” from TH cells, and this allows them to become “killer” or “cytotoxic” T-cells. TC cells have the ability to recognise peptides bound to MHC class I molecules, as opposed to TH cells which recognise peptides ...
Lethal hit delivery by cytotoxic T lymphocytes (CTL) towards B lymphoma cells occurs as a binary, “yes/no” process. In non-hematologic solid tumors, however, CTL often fail to kill target cells during 1:1 conjugation. Here we describe a mechanism of “
The ability of H-2/ and H-2- cell lines to induce or be lysed by cytotoxic T-cells. hnmunogenetics. 4:7.Bevan, M. J., and Hyman, R., The ability of H-2+ and H-2- cell lines to induce or be lysed by cytotoxic T cells. Immunogenetics 4,7, 1978....
Naive/resting CD8+T cells have a staggering ability to respond to pathogens by expansion and differentiation into cytotoxic effector cells that scan the body to clear infection. Deficiency of CD8+T cells hampers anti-tumor immunity and increases susceptibility to tumor ...
Noun1.cytotoxic T cell- T cell with CD8 receptor that recognizes antigens on the surface of a virus-infected cell and binds to the infected cell and kill it CD8 cell,CD8 T cell,killer cell,killer T cell T cell,T lymphocyte- a small lymphocyte developed in the thymus; it orchestrates th...
The ability of H-2+ and H-2− cell lines to induce or be lysed by Cytotoxic T cells We have studied the T cell-mediated lysis of two C58 lymphoma lines: R1(TL + ), which bears serologically detectable H-2 k and TL1,2,3 antigens, and R1(TL − ), an immunoselected variant...
To examine this we used a model examining the ability of native and heteroclitic immunoglobulin (Ig)-derived peptides to generate CTLs that can kill chronic lymphocytic leukemia (CLL) cells. We demonstrate that CTLs generated against heteroclitic peptides have enhanced killing of CD40-activated ...
Among the CD8+ T-cell functions that have most consistently distinguished LTNP/EC from progressors are increased polyfunctionality, proliferation, loading of cytotoxic proteins, virus suppressive ability and cytotoxic capacity (Betts et al., 2006, Ferre et al., 2009, Hersperger et al., 2010, ...
T cells possess superior ability to kill tumor cells1. This killing process occurs at immune synapses formed between CD8+ cytolytic T cells (CTLs) and target tumor cells, where the T cells release pore-forming perforin and pro-apoptotic protease granzymes2,3. Perforin then creates pores in the...
CD4+ T cells can either enhance or inhibit tumour immunity. Although regulatory T cells have long been known to impede antitumour responses1–5, other CD4+ T cells have recently been implicated in inhibiting this response6,7. Yet, the nature and function