cytotoxic T-cell (CTL) functiongeneration of CTL in vitropostprimary infectionHIV-infected infantsHIV-exposed seronegative individualsvaccine developmentcross-clade HIV-specific CTLtreatmentCTL dynamicsplasma viral loaddoi:10.1002/047122393X.CH6M. L. Garba...
Improved understanding of CD8+T cell function during HIV infection is vital to designing an HIV cure. We have identified a subset of lymph node CD8+T cells that demonstrate simultaneous stem-like and effector properties and are strongly associated with viral control during SIV and HIV infection. ...
Adoptive transfer experiments have demonstrated that the CD8+ T cell compartment is centrally responsible for this tumor clearance process (Gorelik and Flavell, 2001). Inhibition of TGF-β signaling in the CD8+ T cell compartment may therefore suffice to restore tumor immunity. However, little is ...
Tumor microenvironment of cancer stem cells: Perspectives on cancer stem cell targeting T cells CytotoxicT lymphocytes(CTLs) are a subset of leukocytes that secrete various cytokines specifically for immune function. These cells build an important defense line of the body's anti-virus and antitumor ...
T cell function can be compromised during chronic infections or through continuous exposure to tumor antigens by the action of immune checkpoint receptors, such as programmed cell death protein 1 (PD-1). Systemic administration of blocking antibodies against the PD-1 pathway can restore T cell fun...
However, the mechanism by which TGF-beta inhibits T cell-mediated tumor clearance in vivo is unknown. We demonstrate that TGF-beta acts on cytotoxic T lymphocytes (CTLs) to specifically inhibit the expression of five cytolytic gene products-namely, perforin, granzyme A, granzyme B, Fas ligand,...
Function:Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. ...
't=it(置於动词前或後与动词连用) T/T电汇 见telegraphic transfer. celln.[C] 1.小房间(如修道院里的密室或狱中的牢房) 2.(蜂房的)巢室 3.电池 4.细胞 5.(尤指革命的)政治活动小组 β cell乙细胞 最新单词 lamella arch怎么翻译及发音叠层拱 ...
cytotoxicTcell每天都是奇迹 关注发消息 头图 自定义头图 主页动态投稿 45 合集和列表 0 收藏 86 追番追剧关注数 1248 粉丝数 222 cytotoxicTcell动态投稿 45 合集和列表 0 收藏 86 追番追剧关注数 1248 粉丝数 222 视频40 音频0 图文5 TA的视频 最新发布 最多播放 最多收藏 播放全部 ...
In recent years, the idea that CD4+ T cells can also play a considerable role in protective anti-tumor responses has received growing attention. One important function of CD4+ T cells is their help for CD8+ T cell and antibody responses against virus or tumor antigens. However, studies ...