cytotoxic T-cell (CTL) functiongeneration of CTL in vitropostprimary infectionHIV-infected infantsHIV-exposed seronegative individualsvaccine developmentcross-clade HIV-specific CTLtreatmentCTL dynamicsplasma viral loaddoi:10.1002/047122393X.CH6M. L. Garba...
Improved understanding of CD8+T cell function during HIV infection is vital to designing an HIV cure. We have identified a subset of lymph node CD8+T cells that demonstrate simultaneous stem-like and effector properties and are strongly associated with viral control during SIV and HIV infection. ...
Adoptive transfer experiments have demonstrated that the CD8+ T cell compartment is centrally responsible for this tumor clearance process (Gorelik and Flavell, 2001). Inhibition of TGF-β signaling in the CD8+ T cell compartment may therefore suffice to restore tumor immunity. However, little is ...
: a T cell that usually bears CD8 molecular markers on its surface and that functions in cell-mediated immunity by destroying a cell (such as a virus-infected cell) having a specific antigenic molecule displayed on its surface Viruses use many tricks to persist in an immunocompetent host, ...
However, the mechanism by which TGF-beta inhibits T cell-mediated tumor clearance in vivo is unknown. We demonstrate that TGF-beta acts on cytotoxic T lymphocytes (CTLs) to specifically inhibit the expression of five cytolytic gene products-namely, perforin, granzyme A, granzyme B, Fas ligand,...
The present report attempts to determine if there are distinct epitopes on the T8 molecule that are involved in class I-restricted cytotoxic T lymphocyte (CTL) function. A panel of 9 monoclonal antibodies (OKT8A,B,C,D,E,F,G,H,I, and OKT5) was produced and all antibodies were shown to...
Cytotoxic T cells (CTLs) are differentiated effector T lymphocytes that specifically kill target cells bearing an appropriate antigenic complex (peptide–MHC) recognized by their T cell receptor. From: Encyclopedia of Immunology (Second Edition), 1998 ...
T cell function can be compromised during chronic infections or through continuous exposure to tumor antigens by the action of immune checkpoint receptors, such as programmed cell death protein 1 (PD-1). Systemic administration of blocking antibodies against the PD-1 pathway can restore T cell fun...
Function:Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. ...
1、细胞毒T细胞（cytotoxic T cell）：消灭受感染的细胞。这些细胞的功能就像一个“杀手”或细胞毒素，因为它们可以对产生特殊抗原反应的目标细胞进行杀灭。细胞毒T细胞的主要表面标志是CD8，也被称为杀手T细胞。2、辅助T细胞（helper T cell）在免疫反应中扮演中间过程的角色：它可以增生扩散来激活其它类型...