利妥昔单抗能特异性结合B细胞上的CD20抗原 ,通过抗体依赖细胞介导的细胞毒作用(ADCC)、抗体依赖性细胞吞噬 (antibody⁃dependent cell⁃mediated phagocytosis,ADCP)和补体依赖性细胞毒作用(complement⁃ dependent cytotoxicity,CDC)等途径杀伤CD20...
Anergic/regulatory (Treg) Immunosuppressive, show reduced IL-2 and IFNγ secretion and proliferation, suppressed cytotoxicity Chronic viral infections Polyclonal or antigen-specific stimulation in the presence of TGFβ+ retinoic acid, TGFβ+ 5-azacytidine CD4 T cell suppr...
we show that sodium chloride (NaCl) counteracts T cell dysfunction to promote cancer regression. NaCl supplementation during CD8+ T cell culture induced effector differentiation, IFN-γ production and cytotoxicity while maintaining the gene networks responsible for stem-like plasticity....
Effective strategies to enhance T cell anti-tumor cytotoxicity are pivotal to improve treatment outcomes. By analyzing tumor samples from patients with head and neck or colon cancers, here the authors show that IL-12 can induce the expression of the inhibitory receptor NKG2A on tumor-reactive CD8...
These FL cases are characterized by abundant infiltration of PD1 CD16 TCRVγ9Vδ2 γδ T lymphocytes. In a 3D co-culture assay (MALC), γδ T cells mediate both direct and indirect (ADCC in the presence of anti-CD20 mAbs) cytolytic activity against FL cell aggregates. Importantly, PD-...
IL-27 promotes tumour control by preventing dysfunction and enhancing cytotoxicity of tumour-specific CD8+T cells. Béatrice Bréart Katherine Williams Nathaniel R. West Research05 Feb 2025Nature P: 1-8 Mapping naturally presented T cell antigens in medulloblastoma based on integrative multi-omics ...
Anergic/regulatory (Treg) Immunosuppressive, show reduced IL-2 and IFNγ secretion and proliferation, suppressed cytotoxicity Chronic viral infections Polyclonal or antigen-specific stimulation in the presence of TGFβ+ retinoic acid, TGFβ+ 5-azacytidine CD4 T cell suppre...
ofcytotoxicity for xenogeneic (mammalian)lymphoma cell lines. The killing of allogeneic cells was not, however, well defined since cells from an individual fish did not discriminate between different allogeneic cell line targets. This lack of allogeneic discrimination was substantiated by the use of ...
Some T-cell cytotoxic reactions require associated antibody (“antibody-dependent T-cell cytotoxicity”) and the presence of “helper cells” (CD4+), which, in contact with activated Tc cells, secrete additional cytokines (Fig. 16.2). Sign in to download full-size image ...
导读：基于抗原特异性T细胞受体工程T细胞(TCR-T)的免疫疗法已被证明是对抗癌症的有效方法。4月13日，中国科学院研究团队在期刊《Cell Death & Disease》上在线发表题为“STING agonist diABZI enhances the cytotoxicity of T cell towards cancer cells”的研究论文，体外和体内数据表明，STING靶向和TCR-T疗法的进展为...