Costimulation tunes tumor-specific activation of redirected T cells in adoptive immunotherapy. Cancer Immunol Immunother 2007; 56: 731-737 [PMID: 17143613 DOI: 10.1007/s00262-006-0249-0]Hombach A, Abken H. Costimulation tunes tumor-specific activation of redi- rected T cells in adoptive ...
T-cell activation is a critical driver of immune responses. The CD28 costimulation is an essential regulator of CD4 T-cell responses, however, its relative importance in naive and memory T cells is not fully understood. Using different model systems, we observe that human memory T cells are mo...
While the prominent role of B7-mediated signaling in the activation of naive and resting T cells has been exhaustively demonstrated, it is unclear whether costimulation is required in the amplification of an initiated immune response. In this study we have developed a multistep culture system to ...
Successful T cell priming in B cell-deficient mice. B cells are an abundant population of lymphocytes that can efficiently capture, process, and present antigen for recognition by activated or memory T cells... Epstein,M M. - 《Journal of Experimental Medicine》 被引量: 605发表: 1995年 Macro...
MPXV M2 impairs T cell activation mediated by B7 costimulation B7-mediated signaling is required for T cell immunity, we then investigated the biological effects of M2 on hB7.1/2 costimulatory functions via an ex vivo T cell activation assay. Purified T cells from peripheral blood mononuclear cel...
Regulation of T cell activation in experimental autoimmune encephalomyelitis: Significance of CD28-mediated costimulation and immune function of CNS-resident cells. 热度: A quantitative analysis of antigen-presenting cell function activated B cells stimulate naive CD4 T cells but are inferior to dendritic...
Following antigen-presentation and costimulation, T cells activate, proliferate, and consequently elicit their effector functions. Functions of T cells include cytolysis of target cells, cytokine production, and B cell stimulation with subsequent antibody production. Their primary function is host defense....
T-Cell Costimulation — Biology, Therapeutic Potential, and Challenges The authors reflect on the biology, therapeutic potential and challenges of T-cell costimulation. They say that T-cells are key mediators of the immune response, and their activation is tightly regulated to prevent autoreactivity....
T cell activationcostimulationimmunotherapyToll-like receptors (TLRs) are among the fundamental molecules that alert the immune system to the presence of an ... N Asprodites,L Zheng,D Geng,... - 《Faseb Journal Official Publication of the Federation of American Societies for Experimental Biology》...
Boosting T cell activation through costimulation directs defense against cancer and viral infections. Despite multiple studies targeting costimulation in clinical trials, the increased potency and reprogramming of T cells endowed by costimulation is poor