T-Cell Costimulation — Biology, Therapeutic Potential, and Challenges The authors reflect on the biology, therapeutic potential and challenges of T-cell costimulation. They say that T-cells are key mediators of the immune response, and their activation is tightly regulated to prevent autoreactivity....
doi:10.1016/S0960-9822(02)00415-3Trevor OwensElsevier BVCurrent BiologyOwens, T: "T-Cell Costimulation: T Cells Themselves Call the Shots." Curr Biol 6, 32-35, 1996.
We have identified the first γδ T cell-specific costimulatory molecule, Junctional Adhesion Molecule-Like protein (JAML) and identify Coxsackie and Adenovirus Receptor (CAR) as its ligand. Only costimulation of epithelial γδ T cells occurs through JAML, αβ-and lymphoid γδ T cells are ...
Yang, S., Wang, Y., Yu, F.et al.Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2.Nat Commun14, 5186 (2023). https://doi.org/10.1038/s41467-023-40748-2 Download citation ...
T-Cell Costimulation and Coinhibition in Graft-Versus-Host Disease and Graft-Versus-Leukemia Effectdoi:10.1016/B978-0-12-812630-1.00011-6Yongxia WuClaudio AnasettiXue-Zhong YuImmune Biology of Allogeneic Hematopoietic Stem Cell Transplantation (Second Edition)...
Boosting T cell activation through costimulation directs defense against cancer and viral infections. Despite multiple studies targeting costimulation in clinical trials, the increased potency and reprogramming of T cells endowed by costimulation is poor
During T cell activation, the engagement of costimulatory molecules is often crucial to the development of an effective immune response, but the mechanism by which this is achieved is not known. Here, it is shown that beads attached to the surface of a T cell translocate toward the interface ...
acids. Th17 cells are particularly sensitive to the inhibition of endogenous acetyl-coenzyme A (acetyl-CoA) carboxylase 1-mediated fatty acid synthesis [5]. Inhibiting fatty acid synthesis not only significantly suppresses Th17 cell subset commitment but also promotes the differentiation of Treg cells....
et al. 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors. Nat Med 21, 581–590 (2015). https://doi.org/10.1038/nm.3838 Download citation Received23 January 2015 Accepted13 March 2015 Published04 May 2015 Issue DateJune 2015 DOIhttps:/...
The costimulation-regulated duration of PKB activation controls T cell longevity. Nat Immunol. 2004;5:150–158.Song J., Salek-Ardakani S., Rogers P. R., Cheng M., Van Parijs L., Croft M. (2004). The costimulation-regulated duration of PKB activation controls T cell longevity . Nat. ...